Armstorfer, Maximilian and Weitgasser, Lennart and Tschani, Stefan and Roesch, Sebastian (2025) Cochlear implantation in patients with autoimmune hearing loss. HNO, 73 (1). pp. 29-34. ISSN 0017-6192, 1433-0458
Full text not available from this repository. (Request a copy)Abstract
Background Autoimmune inner ear disease (AIED) manifests with recurrent fluctuating sensorineural hearing loss and vestibular symptoms. Treatment includes steroids and a variety of immunosuppressants. Despite adequate treatment, sensorineural hearing loss can be progressive to the point of deafness. In these patients, a cochlear implant (CI) is indicated. We present the case of a 25-year-old male who underwent cochlear implantation in the left ear. After implantation we noticed brisk variations in impedances which were related to application of the previously prescribed tumor necrosis alpha (TNF alpha) inhibitor adalimumab. Objective Can immunomodulatory therapy in AIED patients after CI fitting affect the quality of hearing rehabilitation? Materials and methods We documented impedances and speech intelligibility (Freiburg monosyllable test) of our patient for 1 year in dependence on adalimumab therapy. Results Directly after implantation, impedances were within the normal range. During the further course, impedances started to rise, and recurrent adjustments of the implant were needed. Adalimumab therapy was reinitiated, which resulted in a subsequent reduction of impedances. Conclusion Cochlear implantation can be necessary in some AIED patients and poses a sufficient method for hearing rehabilitation. Depending on the activity of the underlying disease, a rise in impedances may occur. Immunomodulatory treatment may therefore be necessary to maintain adequate hearing results with the CI.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INNER-EAR DISEASE; IMMUNE; Hearings aids; Prostheses and implants; Monoclonal antibodies; Tumor necrosis factor inhibitors |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Mar 2026 07:06 |
| Last Modified: | 24 Mar 2026 07:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64651 |
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