Wasilewski, David and Araceli, Tommaso and Bischoff, Philip and Frueh, Anton and Ates, Rober and Murad, Selin and Jung, Niklas and Bukatz, Jan and Samman, Majd and Faust, Katharina and Juenger, Julia and Witzenrath, Martin and Horst, David and Baborie, Atik and Koch, Arend and Capper, David and Heppner, Frank L. and Radbruch, Helena and Riemenschneider, Markus J. and Schmidt, Nils Ole and Vajkoczy, Peter and Proescholdt, Martin and Onken, Julia and Frost, Nikolaj (2025) TTF-1 negativity in synchronous M1b/M1c wildtype lung adenocarcinoma brain metastases predicts worse survival with increased risk of intracranial progression. JOURNAL OF NEURO-ONCOLOGY, 171 (3). pp. 637-649. ISSN 0167-594X, 1573-7373
Full text not available from this repository. (Request a copy)Abstract
Background Thyroid Transcription Factor-1 (TTF-1) expression in lung adenocarcinoma (LUAD) has been studied for its prognostic value in early-stage and metastatic disease. Its role in brain metastasis remains unexplored. This study investigates the predictive value and association of TTF-1 status with clinicopathological variables in patients with synchronous LUAD brain metastases. Material and methods In this bicentric retrospective study, 245 patients with newly diagnosed, treatment-na & iuml;ve brain metastasis undergoing resection were included. Patient data were retrieved from electronic records. Outcomes included overall and progression-free survival. Statistical analysis included Kaplan-Meier estimates and Cox proportional hazards regression. Results Mean Ki67 index in TTF-1 negative patients was 43% [95% CI 38-48%] compared to 32% [95% CI 29-35%] in TTF-1 positive (TTF-1 +) patients (p < 0.001). Tumor volume was significantly larger in TTF-1 negative (TTF-1-) patients (mean volume 24 mL [95% CI 18-31 mL]) vs. 15 mL [95% CI 12-17 mL] in TTF-1 + patients (padjust = 0.003). Perifocal edema was smaller in TTF-1- patients (mean volume: 58 mL [95% CI 45-70 mL]) vs. 84 mL [95% CI 73-94 mL] in TTF-1 + patients (padjust = 0.077). Tumor and edema volume did not correlate. TTF-1- patients showed worse overall, intracranial, and extracranial progression-free survival. In a multivariable Cox model, positive TTF-1 status was independently associated with improved outcomes. Negative TTF-1 status was associated with increased hazard for intracranial disease progression compared to extracranial progression. Conclusion In synchronous LUAD brain metastases, TTF-1 negativity reflects an aggressive phenotype with larger proliferation capacity and tumor volume. Future research should explore the underlying cellular and molecular alterations of this phenotype.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | THYROID TRANSCRIPTION FACTOR-1; FACTOR-I; CARCINOMAS; EXPRESSION; CANCER; KI-67; STAGE; LUAD; Brain Metastasis; TTF-1; Ki67; Tumor volume; Edema volume; Survival |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Neurologie Medicine > Abteilung für Neuropathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Mar 2026 07:46 |
| Last Modified: | 24 Mar 2026 07:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64681 |
Actions (login required)
 |
View Item |
