Reinehr, Sabrina and Pamuk, M. Rahim and Fuchshofer, Rudolf and Dick, H. Burkhard and Joachim, Stephanie C. (2025) Increased inflammation in older high-pressure glaucoma mice. NEUROBIOLOGY OF AGING, 145. pp. 55-64. ISSN 0197-4580, 1558-1497
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Besides an elevated intraocular pressure (IOP), advanced age is one of the most crucial risk factors for developing glaucoma. (3B1-Connective Tissue Growth Factor ((3B1-CTGF) high-pressure glaucoma mice were used in this study to assess whether glaucoma mice display more inflammatory and aging processes than age-matched controls. Therefore, 20-month-old (3B1-CTGF and corresponding wildtype (WT) controls were examined. After IOP measurements, retinas were processed for (immuno-)histological and quantitative real-time PCR analyses. A significantly higher IOP and diminished retinal ganglion cell numbers were noted in (3B1-CTGF mice compared to WT. An enhanced macrogliosis as well as an increased number of microglia/macrophages and microglia was detected in retinas of old glaucoma mice. Interleukin (IL)-1(3, IL-6, tumor necrosis factor-a, and transforming growth factor-(32 were upregulated, suggesting an ongoing inflammation. Moreover, (3B1-CTGF retinas displayed an increased senescence-associated (3-galactosidase staining accompanied by a downregulation of Lmnb1 (laminin-B1) mRNA levels. Our results provide a deeper insight into the association between inflammation and highpressure glaucoma and thus might help to develop new therapy strategies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EPIGENETIC INFORMATION; CELLULAR SENESCENCE; MULLER CELLS; MOUSE MODEL; TNF-ALPHA; AGE; DAMAGE; EXPRESSION; SUSCEPTIBILITY; INTERLEUKIN-6; Aging; Inflammation; Interleukins; Glaucoma; High-pressure; Senescence |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Mar 2026 07:51 |
| Last Modified: | 24 Mar 2026 07:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64705 |
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