Sarac, Diandra Pintac and Tremmel, Martina and Vujetic, Jelena and Torovic, Ljilja and Orcic, Dejan and Popovic, Ljiljana and Mimica-Dukic, Neda and Lesjak, Marija (2024) How do in vitro digestion and cell metabolism affect the biological activity and phenolic profile of grape juice and wine. FOOD CHEMISTRY, 449: 139228. ISSN 0308-8146, 1873-7072
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Cabernet Sauvignon grape juice and wine underwent in vitro digestion, resulting in a reduction of most phenolic compounds (10% - 100% decline), notably impacting anthocyanins (82% - 100% decline) due to pH variations. However, specific phenolics, including p - hydroxybenzoic, protocatechuic, vanillic, p -coumaric, gallic and syringic acids, and coumarin esculetin, increased in concentration (10% - 120%). Grape juice and wine samples showed comparable polyphenolic profile during all phases of digestion. Antioxidant activity persisted, and inhibition of angiotensin-I converting enzyme was improved after the digestion process, likely because of increased concentrations of listed phenolic acids and esculetin. Digested grape juice displayed comparable or superior bioactivity to red wine, indicating it as a promising source of accessible grape polyphenols for a broader audience. Nevertheless, Caco-2 cell model metabolization experiments revealed that only 3 of 42 analyzed compounds passed to the basolateral compartment, emphasizing the significant impact of digestion on polyphenol bioactivity, suggesting potential yet unmeasurable and overlooked implications for human health.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Cabernet sauvignon; Grape juice; Wine; Caco-2 cells; Metabolism; In vitro digestion; Polyphenols |
| Subjects: | 600 Technology > 615 Pharmacy 600 Technology > 640 Home economics & family living |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Nov 2025 07:52 |
| Last Modified: | 27 Nov 2025 07:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64764 |
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