Aminizadeh, Soheil and Moslemizadeh, Amir Hossein and Sheibani, Sara and Sedighi-Khovidak, Zahra and Roholamini, Zahrasadat and Jafarinejad-Farsangi, Saeideh and Kheirandish, Reza and Sheibani, Vahid and Bashiri, Hamideh (2025) Preventive effect of MitoQ supplementation and endurance training on glioblastoma and its consequences: TLR4/CREB/ NF-κβ /IL-1β pathway and behaviors. INTERNATIONAL IMMUNOPHARMACOLOGY, 145: 113756. ISSN 1567-5769, 1878-1705
Full text not available from this repository. (Request a copy)Abstract
Objective: The present study investigated the preventive effect of MitoQ supplementation and endurance training (ET) on the TLR4/CREB/ NF-kappa beta signaling pathway, antioxidant indices, and behaviors in C6-induced glioblastoma (GBM) in rats. Methods: 60 male Wistar rats were randomly divided into five groups (n = 12); Sham, Tumor, MitoQ, ET, and MitoQ + ET. Rats in the training groups performed endurance training (5 days per week), and MitoQ at the dose of 250 mu M/L daily was administered in drinking water for 8 weeks. At the end of the protocol, all groups except the sham group received 1*106 tumor cells /10 mu l culture medium. Two weeks after tumor induction, behavioral tests were performed, and then brain tissue was collected for the histopathology, measurement of antioxidant and inflammatory factors, TLR4, NF-kappa B proteins, and TLR4, NF-kappa beta, CREB, IL-1 ss, TNF-a, IL-10, Bax, Bcl-2, and Caspase-3 gene expression. Results: The increased level of TLR4 and NF-kappa beta protein expression in GBM rats decreased in the treatment groups. Gene expression of TLR4, NF-kappa beta, CREB, TNF-a, IL-10, and Bcl-2 increased in the tumor groups, and treatment groups decreased TLR4, NF-kappa B, Bcl-2, and CREB. In addition, social behaviors, balance, and memory were impaired in the tumor group, which combination group could improve these behaviors. Conclusion: In sum, the preventive effects of MitoQ as a beneficial immune reactive agent and exercise training in rats with C6-induced glioblastoma may be mediated via modulating oxidative stress, inflammatory factors, and down-regulation of the expression of TLR4.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; BREAST-CANCER; IN-VIVO; REGULATES AUTOPHAGY; TNF-ALPHA; ANTIOXIDANT; BRAIN; EXPRESSION; CELLS; Glioblastoma; Endurance training; MitoQ supplementation; Behaviors; TLR4; NF-kappa beta |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Molecular and Cellular Neurobiology (Prof. Dr. Peter J. Flor) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Mar 2026 08:06 |
| Last Modified: | 24 Mar 2026 08:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64794 |
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