Haas, Maximilian and Kriegmair, Maximilian C. and Breyer, Johannes and Sikic, Danijel and Wezel, Felix and Roghmann, Florian and Brehmer, Mirco and Wirtz, Ralph M. and Jarczyk, Jonas and Erben, Philipp and Bahlinger, Veronika and Goldschmidt, Franziska and Fechner, Guido and Chen, Jack and Paxinos, Ellen and Bates, Michael and Zengerling, Friedemann and Bolenz, Christian and Burger, Maximilian and Hartmann, Arndt and Eckstein, Markus (2024) Improving detection of carcinoma in situ in bladder cancer: urinary cytology vs the Xpert® BC Monitor. BJU INTERNATIONAL, 134 (5). pp. 755-762. ISSN 1464-4096, 1464-410X
Full text not available from this repository. (Request a copy)Abstract
ObjectiveTo investigate and compare the performance of urinary cytology and the Xpert BC Monitor test in the detection of bladder cancer in various clinically significant patient cohorts, including patients with carcinoma in situ (CIS), in a prospective multicentre setting, aiming to identify potential applications in clinical practice. Patients and MethodsA total of 756 patients scheduled for transurethral resection of bladder tumour (TURBT) were prospectively screened between July 2018 and December 2020 at six German University Centres. Central urinary cytology and Xpert BC Monitor tests were performed prior to TURBT. The diagnostic performance of urinary cytology and the Xpert BC Monitor was evaluated according to sensitivity (SN), specificity (SC), negative predictive value (NPV) and positive predictive value (PPV). Statistical comparison of urinary cytology and the Xpert BC Monitor was conducted using the McNemar test. ResultsOf 756 screened patients, 733 (568 male [78%]; median [interquartile range] age 72 [62-79] years) were included. Bladder cancer was present in 482 patients (65.8%) with 258 (53.5%) high-grade tumours. Overall SN, SC, NPV and PPV were 39%, 93%, 44% and 92% for urinary cytology, and 75%, 69%, 59% and 82% for the Xpert BC Monitor. In patients with CIS (concomitant or solitary), SN, SC, NPV and PPV were 59%, 93%, 87% and 50% for urinary cytology, and 90%, 69%, 95% and 50% for the Xpert BC Monitor. The Xpert BC Monitor missed four tumours (NPV = 98%) in patients with solitary CIS, while potentially avoiding 63.3% of TURBTs in inconclusive or negative cystoscopy and a negative Xpert result. ConclusionPositive urinary cytology may indicate bladder cancer and should be taken seriously. The Xpert BC Monitor may represent a useful diagnostic tool for correctly identifying patients with solitary CIS and unsuspicious or inconclusive cystoscopy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUALITY-OF-LIFE; TRANSURETHRAL RESECTION; UROTHELIAL CARCINOMA; DIAGNOSIS; EPIDEMIOLOGY; ACCURACY; bladder cancer; carcinoma in situ; cytology; NMIBC; urine marker; Xpert |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Jan 2026 08:02 |
| Last Modified: | 14 Jan 2026 08:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64804 |
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