La Porta, Carmen and Plum, Thomas and Palme, Rupert and Mack, Matthias and Tappe-Theodor, Anke (2024) Repeated social defeat stress differently affects arthritis-associated hypersensitivity in male and female mice. BRAIN BEHAVIOR AND IMMUNITY, 119. pp. 572-596. ISSN 0889-1591, 1090-2139
Full text not available from this repository. (Request a copy)Abstract
Chronic stress enhances the risk of neuropsychiatric disorders and contributes to the aggravation and chronicity of pain. The development of stress-associated diseases, including pain, is affected by individual vulnerability or resilience to stress, although the mechanisms remain elusive. We used the repeated social defeat stress model promoting susceptible and resilient phenotypes in male and female mice and induced knee mono-arthritis to investigate the impact of stress vulnerability on pain and immune system regulation. We analyzed different pain-related behaviors, measured blood cytokine and immune cell levels, and performed histological analyses at the knee joints and pain/stress-related brain areas. Stress susceptible male and female mice showed prolonged arthritis-associated hypersensitivity. Interestingly, hypersensitivity was exacerbated in male but not female mice. In males, stress promoted transiently increased neutrophils and Ly6C(high) monocytes, lasting longer in susceptible than resilient mice. While resilient male mice displayed persistently increased levels of the anti-inflammatory interleukin (IL)-10, susceptible mice showed increased levels of the pro-inflammatory IL-6 at the early- and IL-12 at the late arthritis stage. Although joint inflammation levels were comparable among groups, macrophage and neutrophil infiltration was higher in the synovium of susceptible mice. Notably, only susceptible male mice, but not females, presented microgliosis and monocyte infiltration in the prefrontal cortex at the late arthritis stage. Blood Ly6C(high) monocyte depletion during the early inflammatory phase abrogated late-stage hypersensitivity and the associated histological alterations in susceptible male mice. Thus, recruitment of blood Ly6C(high) monocytes during the early arthritis phase might be a key factor mediating the persistence of arthritis pain in susceptible male mice. Alternative neuro-immune pathways that remain to be explored might be involved in females.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RHEUMATOID-ARTHRITIS; KNEE OSTEOARTHRITIS; BONE-MARROW; DELTA-FOSB; PAIN; INFLAMMATION; BRAIN; RESILIENCE; CYTOKINES; SYSTEM; Social defeat; Arthritis; Pain; Cytokines; Monocytes; Neutrophils; Microglia |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2025 08:33 |
| Last Modified: | 15 Jul 2025 08:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64828 |
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