Hoering, Marcus and Brunner, Sarah and Scheiber, Josef and Honecker, Julius and Liebisch, Gerhard and Seeliger, Claudine and Schinhammer, Laura and Claussnitzer, Melina and Burkhardt, Ralph and Hauner, Hans and Ecker, Josef (2025) Sex-specific response of the human plasma lipidome to short-term cold exposure. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1870 (1): 159567. ISSN 1388-1981, 1879-2618
Full text not available from this repository. (Request a copy)Abstract
Cold-induced lipolysis is widely studied as a potential therapeutic strategy to combat metabolic disease, but its effect on lipid homeostasis in humans remains largely unclear. Blood plasma comprises an enormous repertoire in lipids allowing insights into whole body lipid homeostasis. So far, reported results originate from studies carried out with small numbers of male participants. Here, the blood plasma's lipidome of 78 male and 93 female volunteers, who were exposed to cold below the shivering threshold for 2 h, was quantified by comprehensive lipidomics using high-resolution mass spectrometry. Short-term cold exposure increased the concentrations in 147 of 177 quantified circulating lipids and the response of the plasma's lipidome was sex-specific. In particular, the amounts of generated glycerophospholipid and sphingolipid species differed between the sexes. In women, the BMI could be related with the lipidome's response. A logistic regression model predicted with high sensitivity and specificity whether plasma samples were from male or female subjects based on the cold-induced response of phosphatidylcholine (PC), lysophosphatidylcholine (LPC), and sphingomyelin (SM) species. In summary, cold exposure promotes lipid synthesis by supplying fatty acids generated after lipolysis for all lipid classes. The plasma lipidome, i.e. PC, LPC and SM, shows a sex-specific response, indicating a different regulation of its metabolism in men and women. This supports the need for sex-specific research and avoidance of sex bias in clinical trials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BROWN ADIPOSE-TISSUE; FATTY-ACID; INDUCED THERMOGENESIS; OXIDATIVE-METABOLISM; GENDER-DIFFERENCES; GLUCOSE; LIPOLYSIS; DISEASE; OBESITY; LIVER; Cold exposure; Lipidomics; Lysophosphatidylcholine; Phosphatidylcholine; Plasma lipidome; Sex; Sphingomyelin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Mar 2026 10:11 |
| Last Modified: | 24 Mar 2026 10:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64865 |
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