Goetz, Wolfgang A. and Yao, Jiang and Brener, Michael and Puri, Rishi and Swaans, Martin and Schopka, Simon and Wiesner, Sigrid and Creutzenberg, Marcus and Sievert, Horst and Kassab, Ghassan S. (2024) Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF. BIOENGINEERING-BASEL, 11 (7): 676. ISSN 2306-5354
Full text not available from this repository. (Request a copy)Abstract
Left ventricular (LV) longitudinal function is mechanically coupled to the elasticity of the ascending aorta (AA). The pathophysiologic link between a stiff AA and reduced longitudinal strain and the subsequent deterioration in longitudinal LV systolic function is likely relevant in heart failure with preserved ejection fraction (HFpEF). The proposed therapeutic effect of freeing the LV apex and allowing for LV inverse longitudinal shortening was studied in silico utilizing the Living Left Heart Human Model (Dassault Syst & eacute;mes Simulia Corporation). LV function was evaluated in a model with (A) an elastic AA, (B) a stiff AA, and (C) a stiff AA with a free LV apex. The cardiac model simulation demonstrated that freeing the apex caused inverse LV longitudinal shortening that could abolish the deleterious mechanical effect of a stiff AA on LV function. A stiff AA and impairment of the LV longitudinal strain are common in patients with HFpEF. The hypothesis-generating model strongly suggests that freeing the apex and inverse longitudinal shortening may improve LV function in HFpEF patients with a stiff AA.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | finite element method; computational simulation; aortic stiffness; atrio-ventricular plane displacement; ventricular strain; ventricular function; left ventricular apex; inverse left ventricular shortening; HFpEF |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Nov 2025 08:45 |
| Last Modified: | 26 Nov 2025 08:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64909 |
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