Goetz, Wolfgang Anton and Yao, Jiang and Brener, Michael and Puri, Rishi and Swaans, Martin and Schopka, Simon and Wiesner, Sigrid and Creutzenberg, Marcus and Sievert, Horst and Kassab, Ghassan S. (2024) The Stiffness of the Ascending Aorta Has a Direct Impact on Left Ventricular Function: An In Silico Model. BIOENGINEERING-BASEL, 11 (6): 603. ISSN 2306-5354
Full text not available from this repository. (Request a copy)Abstract
During systole, longitudinal shortening of the left ventricle (LV) displaces the aortic root toward the apex of the heart and stretches the ascending aorta (AA). An in silico study (Living Left Heart Human Model, Dassault Syst & egrave;mes Simulia Corporation) demonstrated that stiffening of the AA affects myocardial stress and LV strain patterns. With AA stiffening, myofiber stress increased overall in the LV, with particularly high-stress areas at the septum. The most pronounced reduction in strain was noted along the septal longitudinal region. The pressure-volume loops showed that AA stiffening caused a deterioration in LV function, with increased end-systolic volume, reduced systolic LV pressure, decreased stroke volume and effective stroke work, but elevated end-diastolic pressure. An increase in myofiber contractility indicated that stroke volume and effective stroke work could be recovered, with an increase in LV end-systolic pressure and a decrease in end-diastolic pressure. Longitudinal and radial strains remained reduced, but circumferential strains increased over baseline, compensating for lost longitudinal LV function. Myofiber stress increased overall, with the most dramatic increase in the septal region and the LV apex. We demonstrate a direct mechanical pathophysiologic link between stiff AA and reduced longitudinal left ventricular strain which are common in patients with HFpEF.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | in silico; finite element method; computational simulation; aortic stiffness; atrioventricular plane displacement; ventricular strain; ventricular function; HFpEF |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Nov 2025 08:48 |
| Last Modified: | 26 Nov 2025 08:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64911 |
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