Salega, Adrian and Muench, Marina and Renner, Philipp and Thon, Klaus-Peter and Steurer, Wolfgang and Moench, Dina and Koch, Jana and Maass, Annika and Schlitt, Hans Jürgen and Dahlke, Marc-Hendrik and Leibold, Tobias (2024) Late Local Recurrence after Neoadjuvant Therapy and Radical Resection for Locally Advanced Rectal Cancer. CANCERS, 16 (2): 448. ISSN 2072-6694
Full text not available from this repository.Abstract
Neoadjuvant radiochemotherapy (RCT) and lately total neoadjuvant therapy (TNT) improved local recurrence rates of rectal cancer significantly compared to total mesorectal excision (TME) alone. Yet the occurrence and impact of late local recurrences after many years appears to be a distinct biological problem. We included n = 188 patients with rectal cancer after RCT and radical resection in this study; n = 38 of which had recurrent disease (sites: local (8.0%), liver (6.4%), lung (3.7%)). We found that 68% of all recurrences developed within the first two years. Four patients, however, experience recurrence >8 years after surgery. Here, we report and characterize four cases of late local recurrence (10% of patients with recurrent disease), suggesting that neoadjuvant therapy in principle delays local recurrence.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TOTAL MESORECTAL EXCISION; LYMPH-NODE DISSECTION; PREOPERATIVE RADIOTHERAPY; PROGNOSTIC-SIGNIFICANCE; FOLLOW-UP; SURVIVAL; CHEMORADIOTHERAPY; MULTICENTER; NOMOGRAMS; SURGERY; rectal cancer; neoadjuvant; radiochemotherapy; outcome; follow-up; surveillance; local recurrence |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jan 2026 07:06 |
| Last Modified: | 22 Jan 2026 07:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64957 |
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