Ahmed, Mohamed I. M. and Einhauser, Sebastian and Peiter, Clemens and Senninger, Antonia and Baranov, Olga and Eser, Tabea M. and Huth, Manuel and Olbrich, Laura and Castelletti, Noemi and Rubio-Acero, Raquel and Carnell, George and Heeney, Jonathan and Kroidl, Inge and Held, Kathrin and Wieser, Andreas and Janke, Christian and Hoelscher, Michael and Hasenauer, Jan and Wagner, Ralf and Geldmacher, Christof (2024) Evolution of protective SARS-CoV-2-specific B and T cell responses upon vaccination and Omicron breakthrough infection. ISCIENCE, 27 (6): 110138. ISSN 2589-0042
Full text not available from this repository. (Request a copy)Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron breakthrough infection (BTI) induced better protection than triple vaccination. To address the underlying immunological mechanisms, we studied antibody and T cell response dynamics during vaccination and after BTI. Each vaccination significantly increased peak neutralization titers with simultaneous increases in circulating spike -specific T cell frequencies. Neutralization titers significantly associated with a reduced hazard rate for SARSCoV-2 infection. Yet, 97% of triple vaccinees became SARS-CoV-2 infected. BTI further boosted neutralization magnitude and breadth, broadened virus -specific T cell responses to non -vaccine -encoded antigens, and protected with an efficiency of 88% from further infections by December 2022. This effect was then assessed by utilizing mathematical modeling, which accounted for time -dependent infection risk, the antibody, and T cell concentration at any time point after BTI. Our findings suggest that cross -variant protective hybrid immunity induced by vaccination and BTI was an important contributor to the reduced virus transmission observed in Bavaria in late 2022 and thereafter.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MODELS |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Jan 2026 09:19 |
| Last Modified: | 14 Jan 2026 09:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64985 |
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