Shen, Yunzhu and Lotenberg, Kenza and Zaworski, Jeremy and Broeker, Katharina A.-E. and Vasseur, Florence and Louedec, Liliane and Placier, Sandrine and Frere, Perrine and Verpont, Marie-Christine and Galichon, Pierre and Buob, David and Hadchouel, Juliette and Terzi, Fabiola and Chatziantoniou, Christos and Calmont, Amelie (2024) Neuropilin-1 regulates renin synthesis in juxtaglomerular cells. JOURNAL OF PHYSIOLOGY-LONDON, 602 (8). pp. 1815-1833. ISSN 0022-3751, 1469-7793
Full text not available from this repository. (Request a copy)Abstract
Renin is the key enzyme of the systemic renin-angiotensin-aldosterone system, which plays an essential role in regulating blood pressure and maintaining electrolyte and extracellular volume homeostasis. Renin is mainly produced and secreted by specialized juxtaglomerular (JG) cells in the kidney. In the present study, we report for the first time that the conserved transmembrane receptor neuropilin-1 (NRP1) participates in the development of JG cells and plays a key role in renin production. We used the myelin protein zero-Cre (P0-Cre) to abrogate Nrp1 constitutively in P0-Cre lineage-labelled cells of the kidney. We found that the P0-Cre precursor cells differentiate into renin-producing JG cells. We employed a lineage-tracing strategy combined with RNAscope quantification and metabolic studies to reveal a cell-autonomous role for NRP1 in JG cell function. Nrp1-deficient animals displayed abnormal levels of tissue renin expression and failed to adapt properly to a homeostatic challenge to sodium balance. These findings provide new insights into cell fate decisions and cellular plasticity operating in P0-Cre-expressing precursors and identify NRP1 as a novel key regulator of JG cell maturation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ell fate; cre-lox; juxtaglomerular cells; lineage tracing; mice; myelin P0 protein; neuropilin-1; renin-angiotensin system |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Dec 2025 05:30 |
| Last Modified: | 10 Dec 2025 05:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/64991 |
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