Schmid, Andreas and Liebisch, Gerhard and Burkhardt, Ralph and Belikan, Hannah and Koehler, Sebastian and Steger, Daniel and Schweitzer, Leonie and Pöns-Kuehnemann, Jörn and Karrasch, Thomas and Schaeffler, Andreas (2024) Dynamics of the human bile acid metabolome during weight loss. SCIENTIFIC REPORTS, 14 (1): 25743. ISSN 2045-2322
Full text not available from this repository.Abstract
Bile acids (BA) are supposed to cause metabolic alterations after bariatric surgery (BS). Here we report the longitudinal dynamics of the human BA metabolome by LC-MS/MS after BS versus low calory diet (LCD) in two obesity cohorts over 12 months. Rapid and persistent oscillations of 23 BA subspecies could be identified with highly specific patterns in BS vs. LCD. TCDCA, GLCA, and TLCA represent most promising candidates for drug development.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Y GASTRIC BYPASS; BARIATRIC SURGERY; GLUCOSE-METABOLISM; INCREASES; OBESITY; Obesity; Bile acids; Bariatric surgery; Low calory diet; Weight loss; Metabolome; Roux-en-Y gastric bypass |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jan 2026 07:29 |
| Last Modified: | 15 Jan 2026 07:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65011 |
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