Haase, Andre and Miroschnikov, Natalia and Klein, Stefan and Doege, Annika and Duenker, Nicole and Van Meenen, Dario and Junker, Andreas and Goepferich, Achim and Apaolaza, Paola Stephanie and Busch, Maike Anna (2024) New retinoblastoma (RB) drug delivery approaches: anti-tumor effect of atrial natriuretic peptide (ANP)-conjugated hyaluronic-acid-coated gold nanoparticles for intraocular treatment of chemoresistant RB. MOLECULAR ONCOLOGY, 18 (4). pp. 832-849. ISSN 1574-7891, 1878-0261
Full text not available from this repository. (Request a copy)Abstract
Intraocular drug delivery is a promising approach for treatment of ocular diseases. Chemotherapeutic drugs used in retinoblastoma (RB) treatment often lead to side effects and drug resistances. Therefore, new adjuvant therapies are needed to treat chemoresistant RBs. Biocompatible gold nanoparticles (GNPs) have unique antiangiogenic properties and can inhibit cancer progression. The combination of gold and low-molecular-weight hyaluronan (HA) enhances the stability of GNPs and promotes the distribution across ocular barriers. Attached to HA-GNPs, the atrial natriuretic peptide (ANP), which diminishes neovascularization in the eye, is a promising new therapeutic agent for RB treatment. In the study presented, we established ANP-coupled HA-GNPs and investigated their effect on the tumor formation potential of chemoresistant RB cells in an in ovo chicken chorioallantoic membrane model and an orthotopic in vivo RB rat eye model. Treatment of etoposide-resistant RB cells with ANP-HA-GNPs in ovo resulted in significantly reduced tumor growth and angiogenesis compared with controls. The antitumorigenic effect could be verified in the rat eye model, including a noninvasive application form via eye drops. Our data suggest that ANP-HA-GNPs represent a new minimally invasive, adjuvant treatment option for RB.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PULMONARY RESECTION; CELL-LINES; CANCER; GROWTH; ANGIOGENESIS; CHEMOTHERAPY; INFLAMMATION; PHENOTYPE; MODEL; ANP; CAM; chemoresistance; gold nanoparticles; hyaluronic acid; retinoblastoma |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Jan 2026 13:46 |
| Last Modified: | 14 Jan 2026 13:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65024 |
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