Fonfara, Melina and Hartmann, Jan and Stoelzl, Dora and Sander, Nicole and Harder, Inken and Rodriguez, Elke and Huebenthal, Matthias and Mazur, Carsten and Kerzel, Sebastian and Kabesch, Michael and Schmitt, Jochen and Emmert, Hila and Suhrkamp, Ina and Weidinger, Stephan (2024) Stratum corneum and microbial biomarkers precede and characterize childhood atopic dermatitis. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 38 (9). pp. 1769-1775. ISSN 0926-9959, 1468-3083
Full text not available from this repository. (Request a copy)Abstract
BackgroundAtopic dermatitis (AD) is the most common paediatric inflammatory skin disease. There are currently no robust biomarkers that could reliably predict its manifestation, and on the molecular level, it is less well characterized than adult AD.ObjectivesThis study aimed to extend previous findings and provide evidence for distinct changes of the epidermal proteome and microbiome preceding the onset of AD as well as characterizing early AD.MethodsWe longitudinally analysed epidermal biomarker levels and microbial profiles in a cohort of 50 neonates at high risk for AD, who had participated in a randomized controlled trial on early emollient use for AD prevention.ResultsAbout 26% of the infants developed AD until month 24 with an average age of 10 month at disease onset. In children with later AD, IL-1Ra, TNF beta, IL-8, IL-18, IL-22, CCL2, TARC, TSLP and VEGFa showed increased levels prior to disease manifestation with levels of IL-1Ra, TNF beta and VEGFa already increased shortly after birth. Further, children with later AD displayed a delayed maturation and differentially composed skin microbiome prior to AD onset. At manifestation, levels of multiple Th2, Th17/22 and Th1-associated biomarkers as well as innate immunity markers were elevated, and abundances of commensal Streptococcus species were reduced in favour of Staphylococcus epidermidis.ConclusionsOur results indicate that elevations of proinflammatory stratum corneum biomarkers and alterations of the skin microbiome precede paediatric AD and characterize the disease at onset.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SKIN MICROBIOME; RISK; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Jan 2026 13:50 |
| Last Modified: | 14 Jan 2026 13:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65028 |
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