Costa, Bibiana and Becker, Jennifer and Krammer, Tobias and Mulenge, Felix and Duran, Veronica and Pavlou, Andreas and Gern, Olivia Luise and Chu, Xiaojing and Li, Yang and Cicin-Sain, Luka and Eiz-Vesper, Britta and Messerle, Martin and Doelken, Lars and Saliba, Antoine-Emmanuel and Erhard, Florian and Kalinke, Ulrich (2024) Human cytomegalovirus exploits STING signaling and counteracts IFN/ISG induction to facilitate infection of dendritic cells. NATURE COMMUNICATIONS, 15 (1): 1745. ISSN 2041-1723
Full text not available from this repository. (Request a copy)Abstract
Human cytomegalovirus (HCMV) is a widespread pathogen that in immunocompromised hosts can cause life-threatening disease. Studying HCMV-exposed monocyte-derived dendritic cells by single-cell RNA sequencing, we observe that most cells are entered by the virus, whereas less than 30% of them initiate viral gene expression. Increased viral gene expression is associated with activation of the stimulator of interferon genes (STING) that usually induces anti-viral interferon responses, and with the induction of several pro- (RHOB, HSP1A1, DNAJB1) and anti-viral (RNF213, TNFSF10, IFI16) genes. Upon progression of infection, interferon-beta but not interferon-lambda transcription is inhibited. Similarly, interferon-stimulated gene expression is initially induced and then shut off, thus further promoting productive infection. Monocyte-derived dendritic cells are composed of 3 subsets, with one being especially susceptible to HCMV. In conclusion, HCMV permissiveness of monocyte-derived dendritic cells depends on complex interactions between virus sensing, regulation of the interferon response, and viral gene expression. Human cytomegalovirus (HCMV) is a ubiquitous pathogen associated with morbidity and mortality in the immunocompromised or immunonaive context. Here the authors show that HCMV exploits STING signalling and subverts the interferon response to support infection of monocyte derive dendritic cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REGULATORY T-CELLS; VIRIONS; ACTIVATION; EXPRESSION; BLOOD; MACROPHAGES; SUBSETS; COMPLEX; CCL18; DEATH |
| Subjects: | 000 Computer science, information & general works > 004 Computer science 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Informatics and Data Science > Department Computational Life Science > Chair of Computational Immunology (Prof. Dr. Florian Erhard) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jan 2026 05:56 |
| Last Modified: | 28 Jan 2026 05:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65044 |
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