Schmitz, Moniek G. J. and Aarts, Jasper G. M. and Burroughs, Laurence and Sudarsanam, Phanikrishna and Kuijpers, Tim J. M. and Riool, Martijn and de Boer, Leonie and Xue, Xuan and Bosnacki, Dragan and Zaat, Sebastian A. J. and de Boer, Jan and Alexander, Morgan R. and Dankers, Patricia Y. W. (2025) Merging Modular Molecular Design with High Throughput Screening of Cell Adhesion on Antimicrobial Supramolecular Biomaterials. MACROMOLECULAR RAPID COMMUNICATIONS, 46 (8). ISSN 1022-1336, 1521-3927
Full text not available from this repository. (Request a copy)Abstract
A polymer microarray based on the supramolecular ureido-pyrimidinone (UPy) moiety is fabricated to screen antimicrobial materials for their ability to support cell adhesion. UPy-functionalized additives, either cell-adhesive, antimicrobial or control peptides, are used, and investigated in different combinations at different concentrations, resulting in a library of 194 spots. These are characterized on composition and morphology to evaluate the microarray fabrication. Normal human dermal fibroblasts are cultured on the microarrays and cell adhesion to the spots is systematically analyzed. Results demonstrate enhanced cell adhesion on spots with combinations including the antimicrobial peptides. This study clearly proves the power of the high throughput approach in combination with supramolecular molecules, to screen additive libraries for desired biological response. Combinatorial high throughput screening using polymer microarrays has become an established method for discovering new biomaterials. This study creates a supramolecular ureido-pyrimidinone (UPy) polymer microarray to screen antimicrobial materials for cell adhesion. Results show enhanced cell adhesion on spots containing (combinations of) antimicrobial peptides. This approach efficiently screens additive libraries for desired biological responses. image
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SURFACE; DIMERIZATION; MICROARRAYS; SCAFFOLDS; DISCOVERY; COATINGS; END; antimicrobial; array; biomaterials; high throughput; screening; supramolecular; upy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Mar 2026 06:12 |
| Last Modified: | 31 Mar 2026 06:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65062 |
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