Orberg, Erik Thiele and Meedt, Elisabeth and Hiergeist, Andreas and Xue, Jinling and Heinrich, Paul and Ru, Jinlong and Ghimire, Sakhila and Miltiadous, Oriana and Lindner, Sarah and Tiefgraber, Melanie and Goeldel, Sophia and Eismann, Tina and Schwarz, Alix and Goettert, Sascha and Jarosch, Sebastian and Steiger, Katja and Schulz, Christian and Gigl, Michael and Fischer, Julius C. and Janssen, Klaus-Peter and Quante, Michael and Heidegger, Simon and Herhaus, Peter and Verbeek, Mareike and Ruland, Juergen and van den Brink, Marcel R. M. and Weber, Daniela and Edinger, Matthias and Wolff, Daniel and Busch, Dirk H. and Kleigrewe, Karin and Herr, Wolfgang and Bassermann, Florian and Gessner, Andre and Deng, Li and Holler, Ernst and Poeck, Hendrik (2024) Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation. NATURE CANCER, 5 (1). pp. 187-208. ISSN 2662-1347
Full text not available from this repository. (Request a copy)Abstract
The microbiome is a predictor of clinical outcome in patients receiving allogeneic hematopoietic stem cell transplantation (allo-SCT). Microbiota-derived metabolites can modulate these outcomes. How bacteria, fungi and viruses contribute to the production of intestinal metabolites is still unclear. We combined amplicon sequencing, viral metagenomics and targeted metabolomics from stool samples of patients receiving allo-SCT (n=78) and uncovered a microbiome signature of Lachnospiraceae and Oscillospiraceae and their associated bacteriophages, correlating with the production of immunomodulatory metabolites (IMMs). Moreover, we established the IMM risk index (IMM-RI), which was associated with improved survival and reduced relapse. A high abundance of short-chain fatty acid-biosynthesis pathways, specifically butyric acid via butyryl-coenzyme A (CoA):acetate CoA-transferase (BCoAT, which catalyzes EC 2.8.3.8) was detected in IMM-RI low-risk patients, and virome genome assembly identified two bacteriophages encoding BCoAT as an auxiliary metabolic gene. In conclusion, our study identifies a microbiome signature associated with protective IMMs and provides a rationale for considering metabolite-producing consortia and metabolite formulations as microbiome-based therapies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; GUT MICROBIOME; ACID; ANTIBIOTICS; DIVERSITY; GUIDE |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Jan 2026 10:31 |
| Last Modified: | 27 Jan 2026 10:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65076 |
Actions (login required)
 |
View Item |
