Ashrafi, Amir M. and Mukherjee, Atripan and Saadati, Arezoo and Matysik, Frank-Michael and Richtera, Lukas and Adam, Vojtech (2024) Enhancing the substrate selectivity of enzyme mimetics in biosensing and bioassay: Novel approaches. ADVANCES IN COLLOID AND INTERFACE SCIENCE, 331: 103233. ISSN 0001-8686, 1873-3727
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A substantial development in nanoscale materials possessing catalytic activities comparable with natural enzymes has been accomplished. Their advantages were owing to the excellent sturdiness in an extreme environment, possibilities of their large-scale production resulting in higher profitability, and easy manipulation for modification. Despite these advantages, the main challenge for artificial enzyme mimetics is the lack of substrate selectivity where natural enzymes flourish. This review addresses this vital problem by introducing substrate selectivity strategies to three classes of artificial enzymes: molecularly imprinted polymers, nanozymes (NZs), and DNAzymes. These rationally designed strategies enhance the substrate selectivity and are discussed and exemplified throughout the review. Various functional mechanisms associated with applying enzyme mimetics in biosensing and bioassays are also given. Eventually, future directives toward enhancing the substrate selectivity of biomimetics and related challenges are discussed and evaluated based on their efficiency and convenience in biosensing and bioassays.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MOLECULARLY IMPRINTED POLYMERS; G-QUADRUPLEX DNAZYME; Nanozymes; Molecularly-imprinted-polymer; DNAzymes; Artificial-enzyme mimetics; Enhanced selectivity |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Instrumentelle Analytik (Prof. Frank-Michael Matysik) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Oct 2025 06:42 |
| Last Modified: | 30 Oct 2025 06:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65114 |
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