Duan, Liyan and Ma, Yuyang and Reisch, Beatrix and Hadrovic, Elina and Mach, Pawel and Kimmig, Rainer and Jahn, Michael and Koeninger, Angela and Iannaccone, Antonella and Gellhaus, Alexandra (2024) Alteration in sB7-H4 Serum Levels and Placental Biomarker Expression after Therapeutic Plasma Exchange in Early-Onset Preeclampsia Patients. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (20): 11082. ISSN 1661-6596, 1422-0067
Full text not available from this repository.Abstract
Therapeutic plasma exchange (TPE) is a widely used treatment for numerous diseases including pregnancy-related conditions. Our prior study on 20 early-onset preeclampsia patients undergoing TPE revealed a significant extension in pregnancy duration and reduced serum levels of sFlt-1, sFlt-1/PlGF, and sEndoglin. Here, we investigated the impact of TPE on serum sB7-H4, an immunological checkpoint molecule, and placental proteins (Flt-1, Eng, B7-H4, iNOS, TNF-alpha) in TPE-treated early-onset preeclampsia patients (N = 12, 23 + 2-28 + 5 weeks), conventionally treated counterparts (N = 12, 23 + 5-30 weeks), and gestational age-matched controls (N = 8, 22 + 4-31 + 6 weeks). Immunoblotting, ELISA, and co-immunohistochemistry were used for biomarker analysis, including placental inflammation factors (iNOS, TNF-alpha). The results showed that TPE extended pregnancy by a median of 6.5 days in this cohort of early-onset preeclampsia. Serum sB7-H4, sFlt-1, and sEndoglin levels decreased, along with reduced expression of their membrane-bound proteins in placental tissue upon TPE treatment. Moreover, TPE-treated patients displayed reduced placental inflammation compared to preeclampsia patients receiving standard-of-care treatment. In conclusion, TPE may improve pregnancy outcomes in early-onset preeclampsia by lowering circulating levels of sB7-H4, sFlt-1, and sEndoglin, as well as reducing placental inflammation. This translational approach holds promise for enhancing placental function and extending gestation in high-risk pregnancies including very preterm PE or HELLP cases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NITRIC-OXIDE SYNTHASE; EXPECTANT MANAGEMENT; PREGNANCY; B7-H4; TERM; PATHOGENESIS; ENDOGLIN; REMOTE; CELLS; WOMEN; therapeutic plasma exchange; preeclampsia; B7-H4; soluble fms-like tyrosine kinase 1; soluble Endoglin; preeclampsia therapy; placental dysfunction; preterm birth |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jan 2026 08:35 |
| Last Modified: | 28 Jan 2026 08:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65231 |
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