Schaubaecher, Johanna B. and Smiljanov, Bojan and Haring, Florian and Steiger, Katja and Wu, Zhengquan and Ugurluoglu, Anais and Luft, Joshua and Ballke, Simone and Mahameed, Shaan and Schneewind, Vera and Hildinger, Jonas and Canis, Martin and Mittmann, Laura A. and Braun, Constanze and Zuchtriegel, Gabriele and Kaiser, Rainer and Nicolai, Leo and Mack, Matthias and Weichert, Wilko and Lauber, Kirsten and Uhl, Bernd and Reichel, Christoph A. (2024) Procoagulant platelets promote immune evasion in triple-negative breast cancer. BLOOD, 144 (2). pp. 216-226. ISSN 0006-4971, 1528-0020
Full text not available from this repository. (Request a copy)Abstract
Triple-negative breast cancer (TNBC) is an aggressive tumor entity in which immune checkpoint (IC) molecules are primarily synthesized in the tumor environment. Here, we report that procoagulant platelets bear large amounts of such immunomodulatory factors and that the presence of these cellular blood components in TNBC relates to protumorigenic immune-cell activity and impaired survival. Mechanistically, tumor-released nucleic acids attract platelets to the aberrant tumor microvasculature, where they undergo procoagulant activation, thus delivering specific stimulatory and inhibitory IC molecules. This concomitantly promotes protumorigenic myeloid leukocyte responses and compromises antitumorigenic lymphocyte activity, ultimately supporting tumor growth. Interference with platelet-leukocyte interactions prevented immune cell misguidance and suppressed tumor progression, nearly as effective as systemic IC inhibition. Hence, our data uncover a self-sustaining mechanism of TNBC by using platelets to misdirect immunecell responses. Targeting this irregular multicellular interplay may represent a novel immunotherapeutic strategy for TNBC without the adverse effects of systemic IC inhibition.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CELLS; INFLAMMATION; NEUTROPHILS; RECEPTORS; BLOCKADE; INSIGHTS; THERAPY; ASPIRIN; GROWTH; LIVER |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jan 2026 07:24 |
| Last Modified: | 22 Jan 2026 07:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65234 |
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