Ebinger, Arnt and Santos, Pauline D. and Pfaff, Florian and Duerrwald, Ralf and Kolodziejek, Jolanta and Schlottau, Kore and Ruf, Viktoria and Liesche-Starnecker, Friederike and Ensser, Armin and Korn, Klaus and Ulrich, Reiner and Fuerstenau, Jenny and Matiasek, Kaspar and Hansmann, Florian and Seuberlich, Torsten and Nobach, Daniel and Mueller, Matthias and Neubauer-Juric, Antonie and Suchowski, Marcel and Bauswein, Markus and Niller, Hans-Helmut and Schmidt, Barbara and Tappe, Dennis and Cadar, Daniel and Homeier-Bachmann, Timo and Haring, Viola C. and Poertner, Kirsten and Frank, Christina and Mundhenk, Lars and Hoffmann, Bernd and Herms, Jochen and Baumgaertner, Wolfgang and Nowotny, Norbert and Schlegel, Juergen and Ulrich, Rainer G. and Beer, Martin and Rubbenstroth, Dennis (2024) Lethal Borna disease virus 1 infections of humans and animals - in-depth molecular epidemiology and phylogeography. NATURE COMMUNICATIONS, 15 (1): 7908. ISSN 2041-1723
Full text not available from this repository. (Request a copy)Abstract
Borna disease virus 1 (BoDV-1) is the causative agent of Borna disease, a fatal neurologic disorder of domestic mammals and humans, resulting from spill-over infection from its natural reservoir host, the bicolored white-toothed shrew (Crocidura leucodon). The known BoDV-1-endemic area is remarkably restricted to parts of Germany, Austria, Switzerland and Liechtenstein. To gain comprehensive data on its occurrence, we analysed diagnostic material from suspected BoDV-1-induced encephalitis cases based on clinical and/or histopathological diagnosis. BoDV-1 infection was confirmed by RT-qPCR in 207 domestic mammals, 28 humans and seven wild shrews. Thereby, this study markedly raises the number of published laboratory-confirmed human BoDV-1 infections and provides a first comprehensive summary. Generation of 136 new BoDV-1 genome sequences from animals and humans facilitated an in-depth phylogeographic analysis, allowing for the definition of risk areas for zoonotic BoDV-1 transmission and facilitating the assessment of geographical infection sources. Consistent with the low mobility of its reservoir host, BoDV-1 sequences showed a remarkable geographic association, with individual phylogenetic clades occupying distinct areas. The closest genetic relatives of most human-derived BoDV-1 sequences were located at distances of less than 40 km, indicating that spill-over transmission from the natural reservoir usually occurs in the patients home region.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTIVIRAL ACTIVITY; RESERVOIR; RIBAVIRIN; SHREWS; MODEL |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jan 2026 06:08 |
| Last Modified: | 28 Jan 2026 06:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65251 |
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