Arcay, Ricardo and Barcelo-Nicolau, Maria and Suarez, Loreto and Martin, Luisa and Reigada, Rebeca and Hoering, Marcus and Liebisch, Gerhard and Garrido, Carmen and Cabot, Gabriel and Vilchez, Helem and Cortes-Lara, Sara and de Herrero, Elisa Gonzalez and Lopez-Causape, Carla and Oliver, Antonio and Barcelo-Coblijn, Gwendolyn and Mena, Ana (2024) Gut microbiome and plasma lipidome analysis reveals a specific impact of Clostridioides difficile infection on intestinal bacterial communities and sterol metabolism. MBIO, 15 (10). ISSN , 2150-7511
Full text not available from this repository. (Request a copy)Abstract
Clostridioides difficile infection (CDI) causes alterations in the intestinal microbiota, frequently associated with changes in the gut metabolism of bile acids and cholesterol. In addition to the impact on microbiome composition and given the metabolic changes occurring during CDI, our work focuses on the importance to know the effects at the local and systemic levels, both during the infection and its treatment, by paying particular attention to plasma lipid metabolism due to its relationship with CDI pathogenesis. Specific changes, characterized by a loss of microbial richness and diversity and related to a reduction in short-chain acid-producing bacteria and an increase in bile salt hydrolase-producing bacteria, were observed in the gut microbiota of CDI patients, especially in those suffering from recurrent CDI (RCDI). However, gut microbiota showed its ability to restore itself after treatment, resembling healthy individuals, in those patients treated by fecal microbiome transfer (FMT), in contrast with those treated with antibiotics, and displaying increased levels of Eubacterium coprostanoligenes, a cholesterol-reducing anaerobe. Interestingly, changes in plasma lipidome revealed a global depletion in circulating lipids in CDI, with the largest impact on cholesteryl esters. CDI patients also showed a specific and consistent decrease in the levels of lipid species containing linoleic acid-an essential fatty acid-which were only partially recovered after antibiotic treatment. Analysis of the plasma lipidome reflects CDI impact on the gut microbiota and its metabolism, evidencing changes in sterol and fatty acid metabolism that are possibly related to specific alterations observed in gut microbial communities of CDI patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SALT HYDROLASE ACTIVITY; POTENTIAL BIOMARKERS; CHOLESTEROL; ACID; OVARIAN; Clostridioides difficile; recurrent CDI; gut microbiota; fecal microbiota transference; plasma lipidome; cholesterol metabolism |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jan 2026 14:58 |
| Last Modified: | 15 Jan 2026 14:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65268 |
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