Steinbrenner, Inga and Kotsis, Fruzsina and Kosch, Robin and Meiselbach, Heike and Baerthlein, Barbara and Stockmann, Helena and Lipovsek, Jan and Zacharias, Helena U. and Altenbuchinger, Michael and Dienemann, Thomas and Wytopil, Monika and Baechle, Helena and Sommerer, Claudia and Titze, Stephanie and Weigel, Anke and Weissensteiner, Hansi and Schonherr, Sebastian and Forer, Lukas and Kurz, Nadine S. and Menne, Jan and Schlieper, Georg and Schneider, Markus P. and Schaeffner, Elke and Kielstein, Jan T. and Sitter, Thomas and Floege, Juergen and Wanner, Christoph and Kronenberg, Florian and Koettgen, Anna and Busch, Martin and Krane, Vera and Schmid, Matthias and Eckardt, Kai-Uwe and Schultheiss, Ulla T. (2024) Interactive exploration of adverse events and multimorbidity in CKD. NEPHROLOGY DIALYSIS TRANSPLANTATION, 39 (12). pp. 2016-2024. ISSN 0931-0509, 1460-2385
Full text not available from this repository. (Request a copy)Abstract
Background Persons with chronic kidney disease (CKD) are at increased risk of adverse events, early mortality and multimorbidity. A detailed overview of adverse event types and rates from a large CKD cohort under regular nephrological care is missing. We generated an interactive tool to enable exploration of adverse events and their combinations in the prospective, observational German CKD (GCKD) study. Methods The GCKD study enrolled 5217 participants under regular nephrological care with an estimated glomerular filtration rate of 30-60 or >60 mL/min/1.73 m2 and an overt proteinuria. Cardiovascular, cerebrovascular and peripheral vascular, kidney, infection, and cancer events, as well as deaths were adjudicated following a standard operation procedure. We summarized these time-to-event data points for exploration in interactive graphs within an R shiny app. Multivariable adjusted Cox models for time to first event were fitted. Cumulative incidence functions, Kaplan-Meier curves and intersection plots were used to display main adverse events and their combinations by sex and CKD etiology. Results Over a median of 6.5 years, 10 271 events occurred in 2947 participants (56.5%), of which 680 participants (13.0%) died. The new publicly available interactive platform enables readers to scrutinize adverse events and their combinations as well as mortality trends as a gateway to better understand multimorbidity in CKD: incident rates per 1000 patient-years varied by event type, CKD etiology and baseline characteristics. Incidence rates for the most frequent events and their recurrence were 113.6 (cardiovascular), 75.0 (kidney) and 66.0 (infection). Participants with presumed diabetic kidney disease and men were more prone to experiencing events. Conclusion This comprehensive explorative tool to visualize adverse events (https://www.gckd.org/studienhintergrund/previous-study-results/event-analysis/), their combination, mortality and multimorbidity among persons with CKD may serve as a valuable resourec for patient care, identification of high-risk groups, health services and public health policy planning.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHRONIC KIDNEY-DISEASE; MORTALITY; RISK; BURDEN; COHORT; DEATH; GCKD; adverse events; chronic kidney disease; epidemiology; interactive visualization; multimorbidity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Jan 2026 09:41 |
| Last Modified: | 27 Jan 2026 09:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65290 |
Actions (login required)
 |
View Item |
