Hansen, Frederik J. and Mittelstaedt, Anke and Clausen, Finn-Niklas and Knoedler, Samuel and Knoedler, Leonard and Kloeckner, Sebastian and Kuchenreuther, Isabelle and Mazurie, Johanne and Arnold, Lisa-Sophie and Anthuber, Anna and Jacobsen, Anne and Merkel, Susanne and Weisel, Nadine and Kloesch, Bettina and Karabiber, Alara and Tacyildiz, Irem and Czubayko, Franziska and Reitberger, Helena and Gendy, Amr El and Brunner, Maximilian and Krautz, Christian and Wolff, Kerstin and Mihai, Sidonia and Neufert, Clemens and Siebler, Juergen and Gruetzmann, Robert and Weber, Georg F. and David, Paul (2024) CD71 expressing circulating neutrophils serve as a novel prognostic biomarker for metastatic spread and reduced outcome in pancreatic ductal adenocarcinoma patients. SCIENTIFIC REPORTS, 14 (1): 21164. ISSN 2045-2322
Full text not available from this repository. (Request a copy)Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, presenting a persisting global health burden. Neutrophils have a double-edged role in tumor progression exhibiting both pro-tumor and anti-tumor functions. CD71, also known as transferrin receptor 1, performs a critical role in cellular iron uptake and is highly expressed on proliferating cells, and especially on activated immune cells. CD71 is known to be elevated in various types of solid cancers and is associated with poor prognosis, however, the expression of CD71 on neutrophils in PDAC and its potential clinical impact is still unknown. Therefore, we analyzed CD71 on circulating neutrophils in PDAC and clinical control patients and found a significant increased expression in PDAC patients. High expression of CD71 on neutrophils in PDAC patients was associated with reduced outcome compared to low expression. CD71 on neutrophils correlated positively with the levels of proinflammatory cytokines IL-6, IFN-gamma, and growth factor ligands CD40-L, and BAFF in plasma of PDAC patients. Finally, we have demonstrated that high expression of CD71 on neutrophils was also associated with an increased expression of CD39 and CD25 on circulating T-cells. Based on our findings, we hypothesize that CD71 on neutrophils is associated with tumor progression in PDAC. Further studies are required to investigate the distinct functionality of CD71 expressing neutrophils and their potential clinical application.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSFERRIN RECEPTOR CD71; IFN-GAMMA; T-CELLS; CANCER; LYMPHOCYTE; ROLES; Pancreatic ductal adenocarcinoma; Neutrophils; CD71; Transferrin receptor 1; Prognostic biomarker; Metastatic spread |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jan 2026 07:55 |
| Last Modified: | 15 Jan 2026 07:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65296 |
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