Gonzalez-Gil, Esther M. and Peruchet-Noray, Laia and Sedlmeier, Anja M. and Christakoudi, Sofia and Biessy, Carine and Navionis, Anne-Sophie and Mahamat-Saleh, Yahya and Jaafar, Rola F. and Baurecht, Hansjoerg and Guevara, Marcela and Etxezarreta, Pilar Amiano and Verschuren, W. M. Monique and Boer, Jolanda M. A. and Olsen, Anja and Tjonneland, Anne and Simeon, Vittorio and Castro-Espin, Carlota and Aune, Dagfinn and Heath, Alicia K. and Gunter, Marc and Colorado-Yohar, Sandra M. and Zilhao, Nuno R. and Dahm, Christina C. and Llanaj, Erand and Schulze, Matthias B. and Petrova, Dafina and Sieri, Sabina and Ricceri, Fulvio and Masala, Giovanna and Key, Tim and Viallon, Vivian and Rinaldi, Sabina and Freisling, Heinz and Dossus, Laure (2024) Association of body shape phenotypes and body fat distribution indexes with inflammatory biomarkers in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank. BMC MEDICINE, 22 (1): 334. ISSN 1741-7015,
Full text not available from this repository.Abstract
BackgroundThe allometric body shape index (ABSI) and hip index (HI), as well as multi-trait body shape phenotypes, have not yet been compared in their associations with inflammatory markers. The aim of this study was to examine the relationship between novel and traditional anthropometric indexes with inflammation using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts.MethodsParticipants from EPIC (n = 17,943, 69.1% women) and UK Biobank (n = 426,223, 53.2% women) with data on anthropometric indexes and C-reactive protein (CRP) were included in this cross-sectional analysis. A subset of women in EPIC also had at least one measurement for interleukins, tumour necrosis factor alpha, interferon gamma, leptin, and adiponectin. Four distinct body shape phenotypes were derived by a principal component (PC) analysis on height, weight, body mass index (BMI), waist (WC) and hip circumferences (HC), and waist-to-hip ratio (WHR). PC1 described overall adiposity, PC2 tall with low WHR, PC3 tall and centrally obese, and PC4 high BMI and weight with low WC and HC, suggesting an athletic phenotype. ABSI, HI, waist-to-height ratio and waist-to-hip index (WHI) were also calculated. Linear regression models were carried out separately in EPIC and UK Biobank stratified by sex and adjusted for age, smoking status, education, and physical activity. Results were additionally combined in a random-effects meta-analysis.ResultsTraditional anthropometric indexes, particularly BMI, WC, and weight were positively associated with CRP levels, in men and women. Body shape phenotypes also showed distinct associations with CRP. Specifically, PC2 showed inverse associations with CRP in EPIC and UK Biobank in both sexes, similarly to height. PC3 was inversely associated with CRP among women, whereas positive associations were observed among men.ConclusionsSpecific indexes of body size and body fat distribution showed differential associations with inflammation in adults. Notably, our results suggest that in women, height may mitigate the impact of a higher WC and HC on inflammation. This suggests that subtypes of adiposity exhibit substantial variation in their inflammatory potential, which may have implications for inflammation-related chronic diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | C-REACTIVE PROTEIN; WAIST CIRCUMFERENCE; ADIPONECTIN LEVELS; COLORECTAL-CANCER; PANCREATIC-CANCER; RISK; OBESITY; MARKERS; HEIGHT; POPULATIONS; Body shape; Height; Anthropometric indicators; Inflammation; C-reactive protein |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Jan 2026 12:11 |
| Last Modified: | 16 Jan 2026 12:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65348 |
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