Rosa, Vinicius and Silikas, Nikolaos and Yu, Baiqing and Dubey, Nileshkumar and Sriram, Gopu and Zinelis, Spiros and Lima, Adriano F. and Bottino, Marco C. and Ferreira, Joao N. and Schmalz, Gottfried and Watts, David C. (2024) Guidance on the assessment of biocompatibility of biomaterials: Fundamentals and testing considerations. DENTAL MATERIALS, 40 (11). pp. 1773-1785. ISSN 0109-5641, 1879-0097
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Background: Assessing the biocompatibility of materials is crucial for ensuring the safety and well-being of patients by preventing undesirable, toxic, immune, or allergic reactions, and ensuring that materials remain functional over time without triggering adverse reactions. To ensure a comprehensive assessment, planning tests that carefully consider the intended application and potential exposure scenarios for selecting relevant assays, cell types, and testing parameters is essential. Moreover, characterizing the composition and properties of biomaterials allows for a more accurate understanding of test outcomes and the identification of factors contributing to cytotoxicity. Precise reporting of methodology and results facilitates research reproducibility and understanding of the findings by the scientific community, regulatory agencies, healthcare providers, and the general public. Aims: This article aims to provide an overview of the key concepts associated with evaluating the biocompatibility of biomaterials while also offering practical guidance on cellular principles, testing methodologies, and biological assays that can support in the planning, execution, and reporting of biocompatibility testing.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DENTAL-PULP CELLS; PERIODONTAL-LIGAMENT CELLS; HUMAN PRIMARY OSTEOBLASTS; MESENCHYMAL STEM-CELLS; IN-VITRO CYTOTOXICITY; ON-A-CHIP; SILVER NANOPARTICLES; CALCIUM HYDROXIDE; CYCLE ARREST; RESIN; Tissue engineering and regeneration; Dental pulp and periodontium; Bioactive materials; Biocompatibility and proliferation; Cell membrane damage; death and apoptosis; Restorative and regenerative materials; Nanoparticles |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Jan 2026 10:23 |
| Last Modified: | 27 Jan 2026 10:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65427 |
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