Schmidt, Axel and Casadei, Nicolas and Brand, Fabian and Demidov, German and Vojgani, Elaheh and Abolhassani, Ayda and Aldisi, Rana and Butler-Laporte, Guillaume and Alawathurage, T. Madhusankha and Augustin, Max and Bals, Robert and Bellinghausen, Carla and Berger, Marc Moritz and Bitzer, Michael and Bode, Christian and Boos, Jannik and Brenner, Thorsten and Cornely, Oliver A. and Eggermann, Thomas and Erber, Johanna and Feldt, Torsten and Fuchsberger, Christian and Gagneur, Julien and Goepel, Siri and Haack, Tobias and Haeberle, Helene and Hanses, Frank and Heggemann, Julia and Hehr, Ute and Hellmuth, Johannes C. and Herr, Christian and Hinney, Anke and Hoffmann, Per and Illig, Thomas and Jensen, Bjoern-Erik Ole and Keitel, Verena and Kim-Hellmuth, Sarah and Koehler, Philipp and Kurth, Ingo and Lanz, Anna-Lisa and Latz, Eicke and Lehmann, Clara and Luedde, Tom and Maj, Carlo and Mian, Michael and Miller, Abigail and Muenchhoff, Maximilian and Pink, Isabell and Protzer, Ulrike and Rohn, Hana and Rybniker, Jan and Scaggiante, Federica and Schaffeldt, Anna and Scherer, Clemens and Schieck, Maximilian and Schmidt, Susanne V. and Schommers, Philipp and Spinner, Christoph D. and Vehreschild, Maria J. G. T. and Velavan, Thirumalaisamy P. and Volland, Sonja and Wilfling, Sibylle and Winter, Christof and Richards, J. Brent and Heimbach, Andre and Becker, Kerstin and Ossowski, Stephan and Schultze, Joachim L. and Nuernberg, Peter and Noethen, Markus M. and Motameny, Susanne and Nothnagel, Michael and Riess, Olaf and Schulte, Eva C. and Ludwig, Kerstin U. (2024) Systematic assessment of COVID-19 host genetics using whole genome sequencing data. PLOS PATHOGENS, 20 (12): e1012786. ISSN 1553-7366, 1553-7374
Full text not available from this repository. (Request a copy)Abstract
Courses of SARS-CoV-2 infections are highly variable, ranging from asymptomatic to lethal COVID-19. Though research has shown that host genetic factors contribute to this variability, cohort-based joint analyses of variants from the entire allelic spectrum in individuals with confirmed SARS-CoV-2 infections are still lacking. Here, we present the results of whole genome sequencing in 1,220 mainly vaccine-naive individuals with confirmed SARS-CoV-2 infection, including 827 hospitalized COVID-19 cases. We observed the presence of autosomal-recessive or likely compound heterozygous monogenic disorders in six individuals, all of which were hospitalized and significantly younger than the rest of the cohort. We did not observe any suggestive causal variants in or around the established risk gene TLR7. Burden testing in the largest population subgroup (i.e., Europeans) suggested nominal enrichments of rare variants in coding and non-coding regions of interferon immune response genes in the overall analysis and male subgroup. Case-control analyses of more common variants confirmed associations with previously reported risk loci, with the key locus at 3p21 reaching genome-wide significance. Polygenic scores accurately captured risk in an age-dependent manner. By enabling joint analyses of different types of variation across the entire frequency spectrum, this data will continue to contribute to the elucidation of COVID-19 etiology.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AUTOANTIBODIES |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Humangenetik Medicine > Abteilung für Krankenhaushygiene und Infektiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jan 2026 06:48 |
| Last Modified: | 28 Jan 2026 06:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65439 |
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