Appel, Katharina S. and Nuernberge, Carolin and Bahmer, Thomas and Foerster, Christian and Polidor, Maria Cristina and Kohls, Mirjam and Kraus, Tanja and Hettich-Damm, Nora and Petersen, Julia and Blaschke, Sabine and Broehl, Isabel and Butzmann, Jana and Dashti, Hiwa and Deckert, Juergen and Dreher, Michael and Fiedler, Karin and Finke, Carsten and Geisler, Ramsia and Hanses, Frank and Hopff, Sina M. and Jensen, Bjoern-Erik O. and Konik, Margarethe and Lehnert, Kristin and de Miranda, Susana M. Nunes and Mitrov, Lazar and Miljuko, Olga and Reese, Jens-Peter and Rohde, Gernot and Scherer, Margarete and Tebbe, Johannes J. and Tausche, Kristin and Vehreschild, Joerg Janne and Voit, Florian and Wagner, Patricia and Weigl, Martin and Lemhoefer, Christina (2024) Definition of the Post-COVID syndrome using a symptom-based Post-COVID score in a prospective, multi-center, cross-sectoral cohort of the German National Pandemic Cohort Network (NAPKON). INFECTION, 52 (5). pp. 1813-1829. ISSN 0300-8126, 1439-0973
Full text not available from this repository. (Request a copy)Abstract
Purpose The objective examination of the Post-COVID syndrome (PCS) remains difficult due to heterogeneous definitions and clinical phenotypes. The aim of the study was to verify the functionality and correlates of a recently developed PCS score. Methods The PCS score was applied to the prospective, multi-center cross-sectoral cohort (in- and outpatients with SARS-CoV-2 infection) of the "National Pandemic Cohort Network (NAPKON, Germany)". Symptom assessment and patient-reported outcome measure questionnaires were analyzed at 3 and 12 months (3/12MFU) after diagnosis. Scores indicative of PCS severity were compared and correlated to demographic and clinical characteristics as well as quality of life (QoL, EQ-5D-5L). Results Six hundred three patients (mean 54.0 years, 60.6% male, 82.0% hospitalized) were included. Among those, 35.7% (215) had no and 64.3% (388) had mild, moderate, or severe PCS. PCS severity groups differed considering sex and pre-existing respiratory diseases. 3MFU PCS worsened with clinical severity of acute infection (p = .011), and number of comorbidities (p = .004). PCS severity was associated with poor QoL at the 3MFU and 12MFU (p < .001). Conclusion The PCS score correlated with patients' QoL and demonstrated to be instructive for clinical characterization and stratification across health care settings. Further studies should critically address the high prevalence, clinical relevance, and the role of comorbidities.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; Post-COVID; Long-COVID; Definition; Score; Patient reported outcome measures; Multi-center prospective cohort study; Quality of life |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Krankenhaushygiene und Infektiologie Medicine > Notfallambulanz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Aug 2025 08:43 |
| Last Modified: | 21 Aug 2025 08:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65486 |
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