Campana, Mattia and Schneider-Axmann, Thomas and Wobrock, Thomas and Malchow, Berend and Langguth, Berthold and Landgrebe, Michael and Eichhammer, Peter and Frank, Elmar and Cordes, Joachim and Woelwer, Wolfgang and Gaebel, Wolfgang and Winterer, Georg and Hajak, Goeran and Ohmann, Christian and Verde, Pablo E. and Rietschel, Marcella and Ahmed, Raees and Mortazavi, Matin and Strube, Wolfgang and Falkai, Peter and Hasan, Alkomiet and Wagner, Elias (2024) Assessing the impact of sex on high-frequency repetitive transcranial magnetic stimulation<acute accent>s clinical response in schizophrenia - results from a secondary analysis. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 25 (4). pp. 233-241. ISSN 1562-2975, 1814-1412
Full text not available from this repository. (Request a copy)Abstract
Background The evidence for repetitive transcranial magnetic stimulation (rTMS) to treat negative symptoms in schizophrenia (SCZ) is increasing, although variable response rates remain a challenge. Subject<acute accent>s sex critically influences rTMS<acute accent> treatment outcomes. Females with major depressive disorder are more likely to respond to rTMS, while SCZ data is scarce. Methods Using data from the 'rTMS for the Treatment of Negative Symptoms in Schizophrenia' (RESIS) trial we assessed the impact of sex on rTMS<acute accent> clinical response rate from screening up to 105 days after intervention among SCZ patients. The impact of resting motor threshold (RMT) on response rates was also assessed. Results 157 patients received either active or sham rTMS treatment. No significant group differences were observed. Linear mixed model showed no effects on response rates (all p > 0.519). Apart from a significant sex*time interaction for the positive subscale of the positive and negative syndrome scale (PANSS) scores (p = 0.032), no other significant effects of sex on continuous PANSS scores were observed. RMT had no effect on response rate. Conclusion In the largest rTMS trial on the treatment of SCZ negative symptoms we did not observe any significant effect of sex on treatment outcomes. Better assessments of sex-related differences could improve treatment individualisation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PREDOMINANT NEGATIVE SYMPTOMS; INTERINDIVIDUAL VARIABILITY; PREDICTORS; RTMS; GENDER; SYSTEM; CORTEX; PANSS; TMS; rTMS; sex; schizophrenia; negative symptoms; RESIS |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Aug 2025 09:01 |
| Last Modified: | 21 Aug 2025 09:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65493 |
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