Trummer, Georg and Benk, Christoph and Pooth, Jan-Steffen and Wengenmayer, Tobias and Supady, Alexander and Staudacher, Dawid L. and Damjanovic, Domagoj and Lunz, Dirk and Wiest, Clemens and Aubin, Hug and Lichtenberg, Artur and Duenser, Martin W. and Szasz, Johannes and Dos Reis Miranda, Dinis and van Thiel, Robert J. and Gummert, Jan and Kirschning, Thomas and Tigges, Eike and Willems, Stephan and Beyersdorf, Friedhelm (2024) Treatment of Refractory Cardiac Arrest by Controlled Reperfusion of the Whole Body: A Multicenter, Prospective Observational Study. JOURNAL OF CLINICAL MEDICINE, 13 (1): 56. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Background: Survival following cardiac arrest (CA) remains poor after conventional cardiopulmonary resuscitation (CCPR) (6-26%), and the outcomes after extracorporeal cardiopulmonary resuscitation (ECPR) are often inconsistent. Poor survival is a consequence of CA, low-flow states during CCPR, multi-organ injury, insufficient monitoring, and delayed treatment of the causative condition. We developed a new strategy to address these issues. Methods: This all-comers, multicenter, prospective observational study (69 patients with in- and out-of-hospital CA (IHCA and OHCA) after prolonged refractory CCPR) focused on extracorporeal cardiopulmonary support, comprehensive monitoring, multi-organ repair, and the potential for out-of-hospital cannulation and treatment. Result: The overall survival rate at hospital discharge was 42.0%, and a favorable neurological outcome (CPC 1+2) at 90 days was achieved for 79.3% of survivors (CPC 1+2 survival 33%). IHCA survival was very favorable (51.7%), as was CPC 1+2 survival at 90 days (41%). Survival of OHCA patients was 35% and CPC 1+2 survival at 90 days was 28%. The subgroup of OHCA patients with pre-hospital cannulation showed a superior survival rate of 57.1%. Conclusions: This new strategy focusing on repairing damage to multiple organs appears to improve outcomes after CA, and these findings should provide a sound basis for further research in this area.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXTRACORPOREAL CARDIOPULMONARY-RESUSCITATION; AMERICAN-HEART-ASSOCIATION; CONTROLLED AUTOMATED REPERFUSION; GLOBAL BRAIN ISCHEMIA; EUROPEAN-RESUSCITATION; LIFE-SUPPORT; VENTRICULAR-FIBRILLATION; NEUROLOGIC RECOVERY; COUNCIL GUIDELINES; OXIDATIVE STRESS; cardiac arrest; cardiopulmonary resuscitation; organ repair; extracorporeal circulation; extracorporeal cardiopulmonary resuscitation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Aug 2025 10:19 |
| Last Modified: | 20 Aug 2025 10:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65515 |
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