Hellstrom, Santtu and Sajanti, Antti and Srinath, Abhinav and Bennett, Carolyn and Girard, Romuald and Cao, Ying and Frantzen, Janek and Koskimaki, Fredrika and Falter, Johannes and Lyne, Sean B. and Rantamaki, Tomi and Takala, Riikka and Posti, Jussi P. and Roine, Susanna and Puolitaival, Jukka and Jankala, Miro and Kolehmainen, Sulo and Rahi, Melissa and Rinne, Jaakko and Castren, Eero and Koskimaki, Janne (2024) Brain Plasticity Modulator p75 Neurotrophin Receptor in Human Urine after Different Acute Brain Injuries-A Prospective Cohort Study. BIOMEDICINES, 12 (1): 112. ISSN , 2227-9059
Full text not available from this repository. (Request a copy)Abstract
Acute brain injuries (ABIs) pose a substantial global burden, demanding effective prognostic indicators for outcomes. This study explores the potential of urinary p75 neurotrophin receptor (p75NTR) concentration as a prognostic biomarker, particularly in relation to unfavorable outcomes. The study involved 46 ABI patients, comprising sub-cohorts of aneurysmal subarachnoid hemorrhage, ischemic stroke, and traumatic brain injury. Furthermore, we had four healthy controls. Samples were systematically collected from patients treated at the University Hospital of Turku between 2017 and 2019, at early (1.50 +/- 0.70 days) and late (9.17 +/- 3.40 days) post-admission time points. Urinary p75NTR levels, measured by ELISA and normalized to creatinine, were compared against patients' outcomes using the modified Rankin Scale (mRS). Early urine samples showed no significant p75NTR concentration difference between favorable and unfavorable mRS groups. In contrast, late samples exhibited a statistically significant increase in p75NTR concentrations in the unfavorable group (p = 0.033), demonstrating good prognostic accuracy (AUC = 70.9%, 95% CI = 53-89%, p = 0.03). Assessment of p75NTR concentration changes over time revealed no significant variation in the favorable group (p = 0.992) but a significant increase in the unfavorable group (p = 0.009). Moreover, p75NTR concentration was significantly higher in ABI patients (mean +/- SD 40.49 +/- 28.83-65.85 +/- 35.04 ng/mg) compared to healthy controls (mean +/- SD 0.54 +/- 0.44 ng/mg), irrespective of sampling time or outcome (p < 0.0001). In conclusion, late urinary p75NTR concentrations emerged as a potential prognostic biomarker for ABIs, showing increased levels associated with unfavorable outcomes regardless of the specific type of brain injury. While early samples exhibited no significant differences, the observed late increases emphasize the time-dependent nature of this potential biomarker. Further validation in larger patient cohorts is crucial, highlighting the need for additional research to establish p75NTR as a reliable prognostic biomarker across various ABIs. Additionally, its potential role as a diagnostic biomarker warrants exploration.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | P75(NTR); BIOMARKER; neurotrophins; brain injury; stroke; trauma; outcome; recovery |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Aug 2025 10:22 |
| Last Modified: | 20 Aug 2025 10:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65516 |
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