van der Speeten, Kurt and Kusamura, Shigeki and Villeneuve, Laurent and Piso, Pompiliu and Verwaal, Vic J. and Gonzalez-Moreno, Santiago and Glehen, Olivier (2024) The 2022 PSOGI International Consensus on HIPEC Regimens for Peritoneal Malignancies: HIPEC Technologies. ANNALS OF SURGICAL ONCOLOGY, 31 (10). pp. 7090-7110. ISSN 1068-9265, 1534-4681
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This manuscript reports the results of an international consensus on technologies of hyperthermic intraperitoneal perioperative chemotherapy (HIPEC) performed with the following goals: To provide recommendations for the technological parameters to perform HIPEC. To identify the role of heat and its application forms in treating peritoneal metastases. To provide recommendations regarding the correct dosimetry of intraperitoneal chemotherapy drugs and their carrier solutions. To identify for each intraperitoneal chemotherapy regimen the best dosimetry and fractionation. To identify areas of future research pertaining to HIPEC technology and regimens. This consensus was performed by the Delphi technique and comprised two rounds of voting. In total, 96 of 102 eligible panelists replied to both Delphi rounds (94.1%) with a consensus of 39/51 questions on HIPEC technical aspects. Among the recommendations that met with the strongest consensus were those concerning the dose of HIPEC drug established in mg/m2, a target temperature of at least 42 degrees C, and the use of at least three temperature probes to pursue hyperthermia. Ninety minutes as the ideal HIPEC duration seemed to make consensus. These results should be considered when designing new clinical trials in patients with peritoneal surface malignancies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; COMPLETE CYTOREDUCTIVE SURGERY; ADVANCED GASTRIC-CANCER; SYNERGISTIC ANTITUMOR-ACTIVITY; HEALTH-CARE WORKERS; DOSE-FINDING TRIAL; LONG-TERM SURVIVAL; QUALITY-OF-LIFE; COLORECTAL-CANCER; OVARIAN-CANCER; Peritoneal Metastases; Cytoreductive Surgery; Intraperitoneal Chemotherapy; Hyperthermia |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Aug 2025 09:45 |
| Last Modified: | 20 Aug 2025 09:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65521 |
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