Hopff, Sina M. and Appel, Katharina S. and Miljukov, Olga and Schneider, Johannes and Addo, Marylyn M. and Bals, Robert and Bercker, Sven and Blaschke, Sabine and Broehl, Isabel and Buechner, Nikolaus and Dashti, Hiwa and Erber, Johanna and Friedrichs, Anette and Geisler, Ramsia and Goepel, Siri and Hagen, Marina and Hanses, Frank and Jensen, Bjoern-Erik Ole and Keul, Maria and Krawczyk, Adalbert and Lorenz-Depiereux, Bettina and Meybohm, Patrick and Milovanovic, Milena and Mitrov, Lazar and Nuernberger, Carolin and Obst, Wilfried and Roemmele, Christoph and Schaefer, Christian and Scheer, Christian and Scherer, Margarete and Schmidt, Julia and Seibel, Kristina and Sikdar, Shimita and Tebbe, Johannes Josef and Tepasse, Phil-Robin and Thelen, Philipp and Vehreschild, Maria J. G. T. and Weismantel, Christina and Vehreschild, J. Janne (2024) Comparison of post-COVID-19 symptoms in patients infected with the SARS-CoV-2 variants delta and omicron-results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network (NAPKON-SUEP). INFECTION, 52 (6). pp. 2253-2267. ISSN 0300-8126, 1439-0973
Full text not available from this repository. (Request a copy)Abstract
PurposeThe influence of new SARS-CoV-2 variants on the post-COVID-19 condition (PCC) remains unanswered. Therefore, we examined the prevalence and predictors of PCC-related symptoms in patients infected with the SARS-CoV-2 variants delta or omicron.MethodsWe compared prevalences and risk factors of acute and PCC-related symptoms three months after primary infection (3MFU) between delta- and omicron-infected patients from the Cross-Sectoral Platform of the German National Pandemic Cohort Network. Health-related quality of life (HrQoL) was determined by the EQ-5D-5L index score and trend groups were calculated to describe changes of HrQoL between different time points.ResultsWe considered 758 patients for our analysis (delta: n = 341; omicron: n = 417). Compared with omicron patients, delta patients had a similar prevalence of PCC at the 3MFU (p = 0.354), whereby fatigue occurred most frequently (n = 256, 34%). HrQoL was comparable between the groups with the lowest EQ-5D-5L index score (0.75, 95% CI 0.73-0.78) at disease onset. While most patients (69%, n = 348) never showed a declined HrQoL, it deteriorated substantially in 37 patients (7%) from the acute phase to the 3MFU of which 27 were infected with omicron.ConclusionWith quality-controlled data from a multicenter cohort, we showed that PCC is an equally common challenge for patients infected with the SARS-CoV-2 variants delta and omicron at least for the German population. Developing the EQ-5D-5L index score trend groups showed that over two thirds of patients did not experience any restrictions in their HrQoL due to or after the SARS-CoV-2 infection at the 3MFU.Clinical Trail registrationThe cohort is registered at ClinicalTrials.gov since February 24, 2021 (Identifier: NCT04768998).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SOUTH-AFRICA; POPULATION; OUTCOMES; Post-covid-19 condition; SARS-CoV-2 variants; Health-related quality of life; Multicenter prospective cohort study |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Krankenhaushygiene und Infektiologie Medicine > Notfallambulanz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Aug 2025 09:57 |
| Last Modified: | 20 Aug 2025 09:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65530 |
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