Moser, Olga and Ngoya, Maud and Galimard, Jacques-Emmanuel and Dalissier, Arnaud and Dalle, Jean Hugues and Kalwak, Krzysztof and Woessmann, Wilhelm and Burkhardt, Birgit and Bierings, Marc and Gonzalez-Vicent, Marta and Corral, Lucia Lopez and Mellgren, Karin and Attarbaschi, Andishe and Bourhis, Jean Henri and Carlson, Kristina and Corbacioglu, Selim and Drabko, Katarzyna and Sundin, Mikael and Toporski, Jacek and Cario, Gunnar and Kontny, Udo (2024) Hematopoietic stem cell transplantation for pediatric patients with non-anaplastic peripheral T-cell lymphoma. An EBMT pediatric diseases working party study. BONE MARROW TRANSPLANTATION, 59 (5). pp. 604-614. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
Peripheral T-cell lymphomas (PTCL) other than anaplastic large-cell lymphoma are rare in children, and the role of hematopoietic stem cell transplantation (HSCT) has not been clarified yet. In a retrospective analysis of registry-data of the European Society for Blood and Marrow Transplantation we analyzed 55 patients aged < 18 years who received allogeneic (N = 46) or autologous (N = 9) HSCT for PTCL. Median age at HSCT was 13.9 years; 33 patients (60%) were in first remission, and 6 (19%) in progression at HSCT. Conditioning was myeloablative in 87% of the allogeneic HSCTs and in 27 (58.7%) based on total body irradiation. After allogeneic HSCT the 5-year overall- and progression-free survival was 58.9% (95% CI 42.7-71.9) and 52.6% (95% CI 36.8-66.1), respectively. 5-year relapse incidence was 27.6% (95% CI 15.1-41.6), the non-relapse mortality rate was 19.8% (95% CI 9.7-32.6). Five of the six patients with progression at HSCT died. Seven of nine patients after autologous HSCT were alive and disease-free at last follow-up. Our data suggest a role of allogeneic HSCT in consolidation-treatment of patients with high-risk disease, who reach at least partial remission after primary- or relapse-therapy, whereas patients with therapy-refractory or progressive disease prior to transplantation do not profit from HSCT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NON-HODGKINS-LYMPHOMAS; RETROSPECTIVE ANALYSIS; ALLOGENEIC TRANSPLANTATION; FREE SURVIVAL; UP-FRONT; CHILDHOOD; CHILDREN; ADOLESCENTS; THERAPY; ADULTS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Aug 2025 09:11 |
| Last Modified: | 20 Aug 2025 09:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65537 |
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