Larue, Marion and Labopin, Myriam and Brissot, Eolia and Alaskar, Ahmed S. and Aljurf, Mahmoud and Arat, Mutlu and Baron, Frederic and Bazarbachi, Ali and Ciceri, Fabio and Corbacioglu, Selim and Dignan, Fiona L. and Kenyon, Michelle and Malard, Florent and Nagler, Arnon and Pagliuca, Antonio and Ruggeri, Annalisa and Yakoub-Agha, Ibrahim and Ye, Yishan and Duarte, Rafael F. and Ruutu, Tapani and Carreras, Enric and Peric, Zinaida and Mohty, Mohamad (2025) An international survey to better understand the current incidence, severity, and management of VOD/SOS. BONE MARROW TRANSPLANTATION, 60 (1). pp. 28-31. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
This international questionnaire survey aimed to explore the current incidence, diagnostic policies, management, and outcomes of veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) among healthcare providers involved in the management of these patients. A questionnaire was e-mailed to practitioners with an interest in allogeneic hematopoietic cell transplantation (allo-HCT). Of the respondents, 144 of 215 (67.0%) felt that early detection or diagnosis of VOD/SOS was difficult. Regarding diagnostic criteria, 142 (66.1%) already declared using the 2023 EBMT refined criteria. Most respondents (163/215, 75.8%) found these recent refined EBMT criteria useful for diagnosis, and 193 (89.8%) found the severity criteria easy to use. The major risk factors identified for VOD/SOS were a second allo-HCT (41.4%), pre-existing liver disease (54.9%), and prior use of antibody-drug conjugates (49.8%). Preferences for starting VOD/SOS treatment varied, with 61 (28.4%) preferring initiating therapy at a mild stage, and 122 (56.7%) preferring the moderate stage. In summary, this survey provided valuable insight into the challenges and opportunities of the identification and management of VOD/SOS. By improving current knowledge and increasing collaboration among healthcare professionals, early detection, management, and clinical outcomes for patients with this potentially serious complication can also be improved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SYNDROME/VENO-OCCLUSIVE DISEASE; VENOOCCLUSIVE DISEASE; EUROPEAN-SOCIETY; CLASSIFICATION; CRITERIA; DEFIBROTIDE; DIAGNOSIS; BLOOD; LIVER; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Apr 2026 10:27 |
| Last Modified: | 07 Apr 2026 10:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65542 |
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