Penack, Olaf and Dreger, Peter and Ajib, Salem and Ayuk, Francis and Baermann, Ben-Niklas and Bug, Gesine and Kriege, Oliver and Jentzsch, Madlen and Kobbe, Guido and Koenecke, Christian and Lutz, Mathias and Martin, Sonja and Schlegel, Paul-Gerhard and Schroers, Roland and von Tresckow, Bastian and Vucinic, Vladan and Subklewe, Marion and Bethge, Wolfgang and Wolff, Daniel (2024) Management of Patients Undergoing CAR-T Cell Therapy in Germany. ONCOLOGY RESEARCH AND TREATMENT, 47 (3). ISSN 2296-5270, 2296-5262
Full text not available from this repository. (Request a copy)Abstract
Introduction: Chimeric antigen receptor positive T cell (CAR-T cell) treatment became standard therapy for relapsed or refractory hematologic malignancies, such as non-Hodgkin's lymphoma and multiple myeloma. Owing to the rapidly progressing field of CAR-T cell therapy and the lack of generally accepted treatment guidelines, we hypothesized significant differences between centers in the prevention, diagnosis, and management of short- and long-term complications. Methods: To capture the current CAR-T cell management among German centers to determine the medical need and specific areas for future clinical research, the DAG-HSZT (Deutsche Arbeitsgemeinschaft fur Hamatopoetische Stammzelltransplantation und Zellulare Therapie; German Working Group for Hematopoietic Stem Cell Transplantation and Cellular Therapy) performed a survey among 26 German CAR-T cell centers. Results: We received answers from 17 centers (65%). The survey documents the relevance of evidence in the CAR-T cell field with a homogeneity of practice in areas with existing clinical evidence. In contrast, in areas with no - or low quality - clinical evidence, we identified significant variety in management in between the centers: management of cytokine release syndrome, immune effector cell-related neurotoxicity syndrome, IgG substitution, autologous stem cell backups, anti-infective prophylaxis, and vaccinations. Conclusion: The results indicate the urgent need for better harmonization of supportive care in CAR-T cell therapies including clinical research to improve clinical outcome.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MULTICENTER; EFFICACY; CAR-T cells; Management; Complications; Infections; Survey |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Aug 2025 08:41 |
| Last Modified: | 20 Aug 2025 08:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65545 |
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