Arslan, Aysenur and Labuhn, Svenja and Sala, Elisa and Ringhoffer, Mark and Schetelig, Johannes and Schroeder, Thomas and Bug, Gesine and Franke, Georg-Nikolaus and Stelljes, Matthias and Dreger, Peter and Zeiser, Robert and Teschner, Daniel and Bethge, Wolfgang and Eder, Matthias and Edinger, Matthias and Amann, Elisa Maria and Neuchel, Christine and Schmid-Moeglich, Amelie and Schmeller, Sandra and Beyersmann, Jan and Schrezenmeier, Hubert and Mytilineos, Joannis and Kroeger, Nicolaus and Fuerst, Daniel (2024) Outcomes of haploidentical transplants with PT-CY vs 10/10 MUDtransplants with ATG in Germany. BLOOD ADVANCES, 8 (23). pp. 6104-6113. ISSN 2473-9529, 2473-9537
Full text not available from this repository. (Request a copy)Abstract
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the best curative treatment modality for many malignant hematologic disorders. In the absence of a matched related donor, matched unrelated donors (MUDs) and haploidentical donors are the most important stem cell sources. In this registry-based retrospective study, we compared the outcomes of allo-HSCTs from 10/10 MUDs with antithymocyte globulin (ATG)-based regimens (n = 7050) vs haploidentical transplants (Haplo-Tx) using posttransplant cyclophosphamide (PT-CY Haplo; n = 487) in adult patients with hematologic malignancies between 2010 and 2020. Cox proportional hazard-and competing risks regression models were formed to compare the outcomes. Overall survival (OS), Disease-free survival (DFS), and graft-versus-host disease (GVHD)-free and relapse-free survival (GRFS) were superior for 10/10 MUDs (OS [hazard ratio (HR), 1.27; 95% confidence interval (CI), 1.10-1.47; P = .001]; DFS [HR, 1.17; CI, 1.02-1.34; P = .022]; GRFS [HR, 1.34; CI, 1.19-1.50; P < .001]). The risk of acute GVHD (aGVHD) grade 2 to 4, aGVHD grade 3 to 4, and chronic GVHD (cGVHD) was higher in the PT-CY Haplo group than the 10/10 MUD group (aGVHD grade 2-4 [HR, 1.46; CI, 1.25-1.71; P < .001]; aGVHD grade 3-4 [HR, 1.74; CI, 1.37- 2.20; P < .001]; cGVHD [HR, 1.30; CI, 1.11-1.51; P = .001]). A lower incidence of relapse was observed in the PT-CY Haplo group (relapse: HR, 0.83; CI, 0.69-0.99; P = .038). Unrelated 10/10 matched transplantation with ATG leads to lower GVHD rates and improved survival rates compared with PT-CY Haplo transplantation in Germany.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELL TRANSPLANTATION; UNRELATED DONOR; POSTTRANSPLANT CYCLOPHOSPHAMIDE; HEMATOLOGIC MALIGNANCIES; MARROW TRANSPLANT; BONE-MARROW; BLOOD; MATCH; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Aug 2025 08:27 |
| Last Modified: | 20 Aug 2025 08:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65559 |
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