Galuba, Viktoria and Cordes, Joachim and Feyerabend, Sandra and Riesbeck, Mathias and Meisenzahl-Lechner, Eva and Correll, Christoph U. and Kluge, Michael and Neff, Andrea and Zink, Mathias and Langguth, Berthold and Reske, Dirk and Gruender, Gerhard and Hasan, Alkomiet and Brockhaus-Dumke, Anke and Jaeger, Markus and Baumgaertner, Jessica and Leucht, Stefan and Schmidt-Kraepelin, Christian (2024) Identifying differential predictors for treatment response to amisulpride and olanzapine combination treatment versus each monotherapy in acutely ill patients with schizophrenia: Results of the COMBINE-study. SCHIZOPHRENIA RESEARCH, 270. pp. 383-391. ISSN 0920-9964, 1573-2509
Full text not available from this repository. (Request a copy)Abstract
Background: Extensive research has been undertaken to predict treatment response (TR) to antipsychotics. Most studies address TR to antipsychotics in general and as monotherapy, however, it is unknown whether patients might respond favourably to a combination of antipsychotics. Aims: This study aimed to identify differential predictors for TR to monotherapy with amisulpride or olanzapine compared to a combination of antipsychotics. Methods: Post-hoc analysis was conducted of data collected from the COMBINE-study, a double-blind, randomized, controlled trial. Demographic and disease-related measures were gathered at baseline to predict TR after eight weeks defined by the Positive and Negative Syndrome Scale. Missing values were accounted for by a random replacement procedure. Attrition effects and multicollinearity were analysed and sets of logistic regression models were calculated for different treatment groups. Results: Of the 321 randomized patients, 201 completed procedures until week eight and 197 were included in the analyses. For all treatment groups, early TR after two weeks and high subjective well-being under antipsychotics at baseline were robust predictors for TR. The propensity for early side effects also indicated a higher risk of later non-response. Specific parameter estimates were rather similar between treatment groups. Conclusion: Early TR, drug-related subjective well-being, and early side effect propensity evolved as predictors for later TR whether to monotherapy or combination strategy. Accordingly, due to a lack of differential predictors, early and close monitoring of targeted and unwanted effects is indicated to guide respective treatment decisions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TREATMENT-RESISTANT SCHIZOPHRENIA; ANTIPSYCHOTIC RESPONSE; REMISSION; DRUG; RECOMMENDATIONS; TRIALS; Schizophrenia; Treatment; Response; Prediction; Antipsychotic; Combination |
| Subjects: | 100 Philosophy & psychology > 150 Psychology 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Aug 2025 08:34 |
| Last Modified: | 18 Aug 2025 08:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65617 |
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