de Jong, Estella and Genders, Roel and Harwood, Catherine A. and Green, Adele C. and Plasmeijer, Elsemieke I. and Proby, Charlotte and Geissler, Edward and Ferrandiz-Pulido, Carla and Ducroux, Emilie and Euvrard, Sylvie and Geusau, Alexandra and Jahn-Bassler, Karin and Borik-Heil, Liliane and Racz, Emo-ke and Nageli, Mirjam and Hofbauer, Gunther F. L. and Piaserico, Stefano and Russo, Irene and Mackintosh, Lorna and Borges-Costa, Joao and Angeliki-Gkini, Maria and Zavattaro, Elisa and Savoia, Paola and Imko-Walszuk, Beata and Dcbska-Slizie, Alicja and Garmyn, Marjan and van Kelst, Sofie and Ricar, Jan and Cetkovska, Petra and Matin, Rubeta and Gulec, Ays Tulin and Seckin, Deniz and Anene, Chinedu Anthony and Oliveira, Walmar R. P. and Rademaker, Marius and Goeman, Jelle and van Geloven, Nan and Ruiz, Emily and Murad, Fadi and Karn, Emily and Schmults, Chrysalyne D. and Bavinck, Jan Nico Bouwes (2024) Cumulative incidence and risk factors for cutaneous squamous cell carcinoma metastases in organ transplant recipients: The Skin Care in Organ Transplant Patients in Europe-International Transplant Skin Cancer Collaborative metastases study, a prospective multicenter study. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 90 (6). pp. 1200-1209. ISSN 0190-9622, 1097-6787
Full text not available from this repository. (Request a copy)Abstract
Introduction: Solid organ transplant recipients (SOTRs) are believed to have an increased risk of metastatic cutaneous squamous cell carcinoma (cSCC), but reliable data are lacking regarding the precise incidence and associated risk factors. Methods: In a prospective cohort study, including 19 specialist dermatology outpatient clinics in 15 countries, patient and tumor characteristics were collected using standardized questionnaires when SOTRs presented with a new cSCC. After a minimum of 2 years of follow-up, relevant data for all SOTRs were collected. Cumulative incidence of metastases was calculated by the Aalen-Johansen estimator. Fine and Gray models were used to assess multiple risk factors for metastases. Results: Of 514 SOTRs who presented with 623 primary cSCCs, metastases developed in 37 with a 2 -year patient -based cumulative incidence of 6.2%. Risk factors for metastases included location in the head and neck area, local recurrence, size [ 2 cm, clinical ulceration, poor differentiation grade, perineural invasion, and deep invasion. A high -stage tumor that is also ulcerated showed the highest risk of metastasis, with a 2 -year cumulative incidence of 46.2% (31.9%-68.4%). Conclusions: SOTRs have a high risk of cSCC metastases and well -established clinical and histologic risk factors have been confirmed. High -stage, ulcerated cSCCs have the highest risk of metastasis. ( J Am Acad Dermatol 2024;90:1200-9.)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RECURRENCE; DEATH; immunosuppression; organ transplantation; skin cancer; squamous cell carcinoma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Aug 2025 06:28 |
| Last Modified: | 14 Aug 2025 06:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65660 |
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