Bos, Saskia and Murray, John and Marchetti, Monia and Cheng, Guang-Shing and Bergeron, Anne and Wolff, Daniel and Sander, Clare and Sharma, Akshay and Badawy, Sherif M. and Peric, Zinaida and Piekarska, Agnieszka and Pidala, Joseph and Raj, Kavita and Penack, Olaf and Kulkarni, Samar and Beestrum, Molly and Linke, Andrea and Rutter, Matthew and Coleman, Courtney and Tonia, Thomy and Schoemans, Helene and Stolz, Daiana and Vos, Robin (2024) ERS/EBMT clinical practice guidelines on treatment of pulmonary chronic graft-versus-host disease in adults. EUROPEAN RESPIRATORY JOURNAL, 63 (3): 2301727. ISSN 0903-1936, 1399-3003
Full text not available from this repository. (Request a copy)Abstract
Chronic graft -versus -host disease (cGvHD) is a common complication after allogeneic haematopoietic stem cell transplantation, characterised by a broad disease spectrum that can affect virtually any organ. Although pulmonary cGvHD is a less common manifestation, it is of great concern due to its severity and poor prognosis. Optimal management of patients with pulmonary cGvHD is complicated and no standardised approach is available. The purpose of this joint European Respiratory Society (ERS) and European Society for Blood and Marrow Transplantation task force was to develop evidence -based recommendations regarding the treatment of pulmonary cGvHD phenotype bronchiolitis obliterans syndrome in adults. A multidisciplinary group representing specialists in haematology, respiratory medicine and methodology, as well as patient advocates, formulated eight PICO (patient, intervention, comparison, outcome) and two narrative questions. Following the ERS standardised methodology, we conducted systematic reviews to address these questions and used the Grading of Recommendations Assessment, Development and Evaluation approach to develop recommendations. The resulting guideline addresses common therapeutic options (inhalation therapy, fluticasone-azithromycin-montelukast, imatinib, ibrutinib, ruxolitinib, belumosudil, extracorporeal photopheresis and lung transplantation), as well as other aspects of general management, such as lung functional and radiological follow-up and pulmonary rehabilitation, for adults with pulmonary cGvHD phenotype bronchiolitis obliterans syndrome. These recommendations include important advancements that could be incorporated in the management of adults with pulmonary cGvHD, primarily aimed at improving and standardising treatment and improving outcomes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BRONCHIOLITIS OBLITERANS SYNDROME; STEM-CELL TRANSPLANTATION; CONSENSUS DEVELOPMENT PROJECT; SOLID-ORGAN TRANSPLANTATION; EXTRACORPOREAL PHOTOPHERESIS; LUNG TRANSPLANTATION; HEMATOPOIETIC SCT; SALVAGE THERAPY; DOUBLE-BLIND; CASE SERIES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Aug 2025 05:41 |
| Last Modified: | 14 Aug 2025 05:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65668 |
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