Holz, Anja and Obi, Nadia and Ahrens, Wolfgang and Berger, Klaus and Bohn, Barbara and Brenner, Hermann and Fischer, Beate and Fricke, Julia and Fuehrer, Amand and Gastell, Sylvia and Greiser, Karin Halina and Harth, Volker and Heise, Jana-Kristin and Holleczek, Bernd and Keil, Thomas and Klett-Tammen, Carolina J. and Leitzmann, Michael and Lieb, Wolfgang and Meinke-Franze, Claudia and Michels, Karin B. and Mikolajczyk, Rafael and Nimptsch, Katharina and Peters, Annette and Pischon, Tobias and Riedel, Oliver and Schikowski, Tamara and Schipf, Sabine and Schmidt, Boerge and Schulze, Matthias B. and Stang, Andreas and Hellwig, Kerstin and Riemann-Lorenz, Karin and Heesen, Christoph and Becher, Heiko (2024) Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO). BMC NEUROLOGY, 24 (1): 123. ISSN , 1471-2377
Full text not available from this repository. (Request a copy)Abstract
Background Multiple Sclerosis (MS) represents the most common inflammatory neurological disease causing disability in early adulthood. Childhood and adolescence factors might be of relevance in the development of MS. We aimed to investigate the association between various factors (e.g., prematurity, breastfeeding, daycare attendance, weight history) and MS risk.Methods Data from the baseline assessment of the German National Cohort (NAKO) were used to calculate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the association between childhood and adolescence factors and risk of MS. Analyses stratified by sex were conducted.Results Among a total of 204,273 participants, 858 reported an MS diagnosis. Male sex was associated with a decreased MS risk (HR 0.48; 95% CI 0.41-0.56), while overweight (HR 2.03; 95% CI 1.41-2.94) and obesity (HR 1.89; 95% CI 1.02-3.48) at 18 years of age compared to normal weight were associated with increased MS risk. Having been breastfed for <= 4 months was associated with a decreased MS risk in men (HR 0.59; 95% CI 0.40-0.86) compared to no breastfeeding. No association with MS risk was observed for the remaining factors.Conclusions Apart from overweight and obesity at the age of 18 years, we did not observe considerable associations with MS risk. The proportion of cases that can be explained by childhood and adolescence factors examined in this study was low. Further investigations of the association between the onset of overweight and obesity in childhood and adolescence and its interaction with physical activity and MS risk seem worthwhile.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EARLY-LIFE; AGE 20; RISK; EXPOSURE; BIRTH; PREVENTION; WEIGHT; Multiple Sclerosis; Childhood; Adolescence; Epidemiology |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Aug 2025 04:36 |
| Last Modified: | 06 Aug 2025 04:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65711 |
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