Assfalg, Volker and Miller, Gregor and Stocker, Felix and Hueser, Norbert and Hartmann, Daniel and Heemann, Uwe and Tieken, Ineke and Zanen, Wouter and Vogelaar, Serge and Rosenkranz, Alexander R. and Schneeberger, Stefan and Fuegger, Reinhold and Berlakovich, Gabriela and Ysebaert, Dirk R. and Jacobs-Tulleneers-Thevissen, Daniel and Mikhalski, Dimitri and van Laecke, Steven and Kuypers, Dirk and Muehlfeld, Anja S. and Viebahn, Richard and Pratschke, Johann and Melchior, Sebastian and Hauser, Ingeborg A. and Jaenigen, Bernd and Weimer, Rolf and Richter, Nicolas and Foller, Susan and Schulte, Kevin and Kurschat, Christine and Harth, Ana and Moench, Christian and Rademacher, Sebastian and Nitschke, Martin and Kraemer, Bernhard K. and Renders, Lutz and Koliogiannis, Dionysios and Pascher, Andreas and Hoyer, Joachim and Weinmann-Menke, Julia and Schiffer, Mario and Banas, Bernhard and Hakenberg, Oliver and Schwenger, Vedat and Nadalin, Silvio and Lopau, Kai and Piros, Laszlo and Nemes, Balazs and Szakaly, Peter and Bouts, Antonia and Bemelman, Frederike J. and Sanders, Jan S. and de Vries, Aiko P. J. and Christiaans, Maarten H. L. and Hilbrands, Luuk and van Zuilen, Arjan D. and Arnol, Miha and Stippel, Dirk and Wahba, Roger (2024) Rescue Allocation Modes in Eurotransplant Kidney Transplantation: Recipient Oriented Extended Allocation Versus Competitive Rescue Allocation-A Retrospective Multicenter Outcome Analysis. TRANSPLANTATION, 108 (5). pp. 1200-1211. ISSN 0041-1337, 1534-6080
Full text not available from this repository. (Request a copy)Abstract
Background. Whenever the kidney standard allocation (SA) algorithms according to the Eurotransplant (ET) Kidney Allocation System or the Eurotransplant Senior Program fail, rescue allocation (RA) is initiated. There are 2 procedurally different modes of RA: recipient oriented extended allocation (REAL) and competitive rescue allocation (CRA). The objective of this study was to evaluate the association of patient survival and graft failure with RA mode and whether or not it varied across the different ET countries.Methods. The ET database was retrospectively analyzed for donor and recipient clinical and demographic characteristics in association with graft outcomes of deceased donor renal transplantation (DDRT) across all ET countries and centers from 2014 to 2021 using Cox proportional hazards methods.Results. Seventeen thousand six hundred seventy-nine renal transplantations were included (SA 15 658 [89%], REAL 860 [4.9%], and CRA 1161 [6.6%]). In CRA, donors were older, cold ischemia times were longer, and HLA matches were worse in comparison with REAL and especially SA. Multivariable analyses showed comparable graft and recipient survival between SA and REAL; however, CRA was associated with shorter graft survival. Germany performed 76% of all DDRTs after REAL and CRA and the latter mode reduced waiting times by up to 2.9 y.Conclusions. REAL and CRA are used differently in the ET countries according to national donor rates. Both RA schemes optimize graft utilization, lead to acceptable outcomes, and help to stabilize national DDRT programs, especially in Germany.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COLD ISCHEMIA TIME; GRAFT-SURVIVAL; RISK; ASSOCIATION; MORTALITY; DIALYSIS; FAILURE; SYSTEM; DONORS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Jul 2025 09:50 |
| Last Modified: | 23 Jul 2025 09:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65747 |
Actions (login required)
 |
View Item |
