Mikolajczyk, Rafael and Diexer, Sophie and Klee, Bianca and Pfrommer, Laura and Purschke, Oliver and Fricke, Julia and Ahnert, Peter and Gabrysch, Sabine and Gottschick, Cornelia and Bohn, Barbara and Brenner, Hermann and Buck, Christoph and Castell, Stefanie and Gastell, Sylvia and Greiser, Karin Halina and Harth, Volker and Heise, Jana-Kristin and Holleczek, Bernd and Kaaks, Rudolf and Keil, Thomas and Krist, Lilian and Leitzmann, Michael and Lieb, Wolfgang and Meinke-Franze, Claudia and Michels, Karin B. and Velasquez, Ilais Moreno and Obi, Nadia and Panreck, Leo and Peters, Annette and Pischon, Tobias and Schikowski, Tamara and Schmidt, Borge and Standl, Marie and Stang, Andreas and Voelzke, Henry and Weber, Andrea and Zeeb, Hajo and Karch, Andre (2024) Likelihood of Post-COVID Condition in people with hybrid immunity; data from the German National Cohort (NAKO). JOURNAL OF INFECTION, 89 (2): 106206. ISSN 0163-4453, 1532-2742
Full text not available from this repository. (Request a copy)Abstract
Objectives: The risk of Post-COVID-19 condition (PCC) under hybrid immunity remains unclear. Methods: Using data from the German National Cohort (NAKO Gesundheitsstudie), we investigated risk factors for self-reported post-infection symptoms (any PCC is defined as having at least one symptom, and high symptom burden PCC as having nine or more symptoms). Results: Sixty percent of 109,707 participants reported at least one previous SARS-CoV-2 infection; 35% reported having had any symptoms 4-12 months after infection; among them 23% reported nine or more symptoms. Individuals, who did not develop PCC after their first infection, had a strongly reduced risk for PCC after their second infection (50%) and a temporary risk reduction, which waned over 9 months after the preceding infection. The risk of developing PCC strongly depended on the virus variant. Within variants, there was no effect of the number of preceding vaccinations, apart from a strong protection by the fourth vaccination compared to three vaccinations for the Omicron variant (odds ratio = 0.52; 95% confidence Conclusions: Previous infections without PCC and a fourth vaccination were associated with a lower risk of PCC after a new infection, indicating diminished risk under hybrid immunity. The two components of risk (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; SARS-CoV-2; Post-COVID-19 condition; Reinfection; Hybrid immunity; Vaccination |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Jul 2025 09:40 |
| Last Modified: | 23 Jul 2025 09:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65749 |
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