Wang, Justin Z. and Patil, Vikas and Landry, Alexander P. and Gui, Chloe and Ajisebutu, Andrew and Liu, Jeff and Saarela, Olli and Pugh, Stephanie L. and Won, Minhee and Patel, Zeel and Yakubov, Rebeca and Kaloti, Ramneet and Wilson, Christopher and Cohen-Gadol, Aaron and Zaazoue, Mohamed A. and Tabatabai, Ghazaleh and Tatagiba, Marcos and Behling, Felix and Bonnin, Damian A. Almiron and Holland, Eric C. and Kruser, Tim J. and Barnholtz-Sloan, Jill S. and Sloan, Andrew E. and Horbinski, Craig and Chotai, Silky and Chambless, Lola B. and Gao, Andrew and Rebchuk, Alexander D. and Makarenko, Serge and Yip, Stephen and Sahm, Felix and Maas, Sybren L. N. and Tsang, Derek S. and Rogers, C. Leland and Aldape, Kenneth and Nassiri, Farshad and Zadeh, Gelareh and McDermott, Michael W. and Santarius, Thomas and Selman, Warren and Couce, Marta and Carvalho, Bruno and Wen, Patrick Y. and Walsh, Kyle M. and Bos, Eelke M. and Bi, Wenya Linda and Huang, Raymond Y. and Brastianos, Priscilla K. and Shih, Helen A. and Walbert, Tobias and Lee, Ian and Felicella, Michelle M. and Castro, Ana Valeria and Noushmehr, Houtan and Snyder, James M. and Dimeco, Francesco and Saladino, Andrea and Pollo, Bianca and Schichor, Christian and Tonn, Joerg-Christian and Ehret, Felix and Kaufmann, Timothy J. and Lachance, Daniel H. and Giannini, Caterina and Galanis, Evanthia and Raghunathan, Aditya and Vogelbaum, Michael A. and Barnholtz-Sloan, Jill and Cimino, Patrick J. and Horbinski, Craig M. and Youngblood, Mark and Snuderl, Matija and Kurz, Sylvia C. and Sulman, Erik P. and Dunn, Ian F. and Hanemann, C. Oliver and Javadpour, Mohsen and Ng, Ho-Keung and Boutros, Paul C. and Everson, Richard G. and Tzannis, Alkiviadis and Fountas, Konstantinos N. and Schmidt, Nils Ole and Au, Karolyn and Goldbrunner, Roland and Galldiks, Norbert and Timmer, Marco and Mathiesen, Tiit Illimar and Westphal, Manfred and Lamszus, Katrin and Ricklefs, Franz L. and Herold-Mende, Christel and Jungk, Christine and Jungwirth, Gerhard and von Deimling, Andreas and Deng, Maximilian and Short, Susan C. and Jenkinson, Michael D. and Mawrin, Christian and Islim, Abdurrahman I. and Fountain, Daniel M. and Pathmanaban, Omar N. and Drummond, Katharine J. and Morokoff, Andrew and Raleigh, David R. and Perry, Arie and Butowski, Nicholas A. and Malta, Tathiane M. and Zherebitskiy, Viktor and Hnenny, Luke and Zada, Gabriel and Renovanz, Mirjam and Santacroce, Antonio and la Fougere, Christian and Schittenhelm, Jens and Passlack, Paul and Moliterno, Jennifer and Dincer, Alper (2024) Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma. NATURE MEDICINE, 30 (11). 3173-+. ISSN 1078-8956, 1546-170X
Full text not available from this repository. (Request a copy)Abstract
Treatment of the tumor and dural margin with surgery and sometimes radiation are cornerstones of therapy for meningioma. Molecular classifications have provided insights into the biology of disease; however, response to treatment remains heterogeneous. In this study, we used retrospective data on 2,824 meningiomas, including molecular data on 1,686 tumors and 100 prospective meningiomas, from the RTOG-0539 phase 2 trial to define molecular biomarkers of treatment response. Using propensity score matching, we found that gross tumor resection was associated with longer progression-free survival (PFS) across all molecular groups and longer overall survival in proliferative meningiomas. Dural margin treatment (Simpson grade 1/2) prolonged PFS compared to no treatment (Simpson grade 3). Molecular group classification predicted response to radiotherapy, including in the RTOG-0539 cohort. We subsequently developed a molecular model to predict response to radiotherapy that discriminates outcome better than standard-of-care classification. This study highlights the potential for molecular profiling to refine surgical and radiotherapy decision-making.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ORGANIZATION GRADE I; MODERN NEUROSURGICAL TREATMENT; SIMPSON GRADE; ADJUVANT RADIOTHERAPY; RESECTION; RECURRENCE; RELEVANCE; SYSTEM; MULTICENTER; EFFICACY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Jul 2025 08:44 |
| Last Modified: | 23 Jul 2025 08:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65763 |
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