Garcia-Marin, Luis M. and Campos, Adrian I. and Diaz-Torres, Santiago and Rabinowitz, Jill A. and Ceja, Zuriel and Mitchell, Brittany L. and Grasby, Katrina L. and Thorp, Jackson G. and Agartz, Ingrid and Alhusaini, Saud and Ames, David and Amouyel, Philippe and Andreassen, Ole A. and Arfanakis, Konstantinos and Arias-Vasquez, Alejandro and Armstrong, Nicola J. and Athanasiu, Lavinia and Bastin, Mark E. and Beiser, Alexa S. and Bennett, David A. and Bis, Joshua C. and Boks, Marco P. M. and Boomsma, Dorret I. and Brodaty, Henry and Brouwer, Rachel M. and Buitelaar, Jan K. and Burkhardt, Ralph and Cahn, Wiepke and Calhoun, Vince D. and Carmichael, Owen T. and Chakravarty, Mallar and Chen, Qiang and Ching, Christopher R. K. and Cichon, Sven and Crespo-Facorro, Benedicto and Crivello, Fabrice and Dale, Anders M. and Smith, George Davey and de Geus, Eco J. C. and De Jager, Philip L. and de Zubicaray, Greig I. and Debette, Stephanie and DeCarli, Charles and Depondt, Chantal and Desrivieres, Sylvane and Djurovic, Srdjan and Ehrlich, Stefan and Erk, Susanne and Espeseth, Thomas and Fernandez, Guillen and Filippi, Irina and Fisher, Simon E. and Fleischman, Debra A. and Fletcher, Evan and Fornage, Myriam and Forstner, Andreas J. and Francks, Clyde and Franke, Barbara and Ge, Tian and Goldman, Aaron L. and Grabe, Hans J. and Green, Robert C. and Grimm, Oliver and Groenewold, Nynke A. and Gruber, Oliver and Gudnason, Vilmundur and Haberg, Asta K. and Haukvik, Unn K. and Heinz, Andreas and Hibar, Derrek P. and Hilal, Saima and Himali, Jayandra J. and Ho, Beng-Choon and Hoehn, David F. and Hoekstra, Pieter J. and Hofer, Edith and Hoffmann, Wolfgang and Holmes, Avram J. and Homuth, Georg and Hosten, Norbert and Ikram, M. Kamran and Ipser, Jonathan C. and Jack, Clifford R. and Jahanshad, Neda and Joensson, Erik G. and Kahn, Rene S. and Kanai, Ryota and Klein, Marieke and Knol, Maria J. and Launer, Lenore J. and Lawrie, Stephen M. and Le Hellard, Stephanie and Lee, Phil H. and Lemaitre, Herve and Li, Shuo and Liewald, David C. M. and Lin, Honghuang and Longstreth, W. T. and Lopez, Oscar L. and Luciano, Michelle and Maillard, Pauline and Marquand, Andre F. and Martin, Nicholas G. and Martinot, Jean-Luc and Mather, Karen A. and Mattay, Venkata S. and McMahon, Katie L. and Mecocci, Patrizia and Melle, Ingrid and Meyer-Lindenberg, Andreas and Mirza-Schreiber, Nazanin and Milaneschi, Yuri and Mosley, Thomas H. and Muehleisen, Thomas W. and Mueller-Myhsok, Bertram and Maniega, Susana Munoz and Nauck, Matthias and Nho, Kwangsik and Niessen, Wiro J. and Noethen, Markus M. and Nyquist, Paul A. and Oosterlaan, Jaap and Pandolfo, Massimo and Paus, Tomas and Pausova, Zdenka and Penninx, Brenda W. J. H. and Pike, G. Bruce and Psaty, Bruce M. and Puetz, Benno and Reppermund, Simone and Rietschel, Marcella D. and Risacher, Shannon L. and Romanczuk-Seiferth, Nina and Romero-Garcia, Rafael and Roshchupkin, Gennady V. and Rotter, Jerome I. and Sachdev, Perminder S. and Saemann, Philipp G. and Saremi, Arvin and Sargurupremraj, Muralidharan and Saykin, Andrew J. and Schmaal, Lianne and Schmidt, Helena and Schmidt, Reinhold and Schofield, Peter R. and Scholz, Markus and Schumann, Gunter and Schwarz, Emanuel and Shen, Li and Shin, Jean and Sisodiya, Sanjay M. and Smith, Albert V. and Smoller, Jordan W. and Soininen, Hilkka S. and Steen, Vidar M. and Stein, Dan J. and Stein, Jason L. and Thomopoulos, Sophia I. and Toga, Arthur W. and Tordesillas-Gutierrez, Diana and Trollor, Julian N. and Valdes-Hernandez, Maria C. and van't Ent, Dennis and van Bokhoven, Hans and van der Meer, Dennis and van der Wee, Nic J. A. and Vazquez-Bourgon, Javier and Veltman, Dick J. and Vernooij, Meike W. and Villringer, Arno and Vinke, Louis N. and Voelzke, Henry and Walter, Henrik and Wardlaw, Joanna M. and Weinberger, Daniel R. and Weiner, Michael W. and Wen, Wei and Westlye, Lars T. and Westman, Eric and White, Tonya and Witte, A. Veronica and Wolf, Christiane and Yang, Jingyun and Zwiers, Marcel P. and Ikram, M. Arfan and Seshadri, Sudha and Thompson, Paul M. and Satizabal, Claudia L. and Medland, Sarah E. and Renteria, Miguel E. (2024) Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. NATURE GENETICS, 56 (11). 2333-+. ISSN 1061-4036, 1546-1718
Full text not available from this repository. (Request a copy)Abstract
Subcortical brain structures are involved in developmental, psychiatric and neurological disorders. Here we performed genome-wide association studies meta-analyses of intracranial and nine subcortical brain volumes (brainstem, caudate nucleus, putamen, hippocampus, globus pallidus, thalamus, nucleus accumbens, amygdala and the ventral diencephalon) in 74,898 participants of European ancestry. We identified 254 independent loci associated with these brain volumes, explaining up to 35% of phenotypic variance. We observed gene expression in specific neural cell types across differentiation time points, including genes involved in intracellular signaling and brain aging-related processes. Polygenic scores for brain volumes showed predictive ability when applied to individuals of diverse ancestries. We observed causal genetic effects of brain volumes with Parkinson's disease and attention-deficit/hyperactivity disorder. Findings implicate specific gene expression patterns in brain development and genetic variants in comorbid neuropsychiatric disorders, which could point to a brain substrate and region of action for risk genes implicated in brain diseases. Genome-wide association analyses of intracranial and nine subcortical brain volumes in 74,898 participants of European ancestry identify 254 independent loci and yield polygenic scores accounting for brain variation across ancestries.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | WIDE ASSOCIATION; GENETIC ARCHITECTURE; METAANALYSES; LOCI; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Jul 2025 08:51 |
| Last Modified: | 23 Jul 2025 08:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65764 |
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