Lippert, Elisabeth and Ruemmele, Petra and Obermeier, Florian and Goelder, Stefan and Kunst, Claudia and Rogler, Gerhard and Dunger, Nadja and Messmann, Helmut and Hartmann, Arndt and Endlicher, Esther (2017) Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model. DIGESTION, 95 (4). pp. 275-280. ISSN 0012-2823, 1421-9867
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Background: Colorectal cancer is the main leading cause of cancer-related deaths worldwide. Present data suggest that plant-derived anthocyanins have anti-inflammatory and chemopreventive properties. This study was aimed at evaluating the effect of an anthocyanin-rich extract from bilberries on colorectal tumour development and growth in the administration of azoxymethan (AOM)/dextran sodium sulfate (DSS) mouse model. Methods: Colonic carcinogenesis was induced by AOM and DSS 3 or 5%, respectively, in 50 female Balb/c mice. Mice received either normal food (controls) or a diet containing either 10 or 1% anthocyanin-rich bilberry extract. Colonoscopy took place at week 4 and 9 after initiation of carcinogenesis. After termination at week 9, colon samples were analysed macroscopically and microscopically. Results: Mice receiving 10% anthocyanins showed significantly (p < 0.004) less reduced colon length (12.1 cm [8.5-14.4 cm]) as compared to controls (11.2 cm [9.8-12.3]) indicating less inflammation. Mice fed with 10% anthocyanin-rich extract revealed significantly less mean tumour numbers (n = 1.2) compared to control (n = 14) and anthocyanin 1% treated mice (n = 10.6, p < 0.001). Conclusion: Anthocyanins prevented the formation and growth of colorectal cancer in AOM/DSS-treated Balb/c mice. Further studies should investigate the mechanisms of how anthocyanins influence the development of colorectal cancer. (C) 2017 S. Karger AG, Basel.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CELL-PROLIFERATION; RICH EXTRACTS; APC(MIN) MICE; COLITIS; INHIBITION; RISK; EXPRESSION; VEGETABLES; APOPTOSIS; BILBERRY; Anthocyanin; Colorectal cancer; Inflammation; Endoscopy; Administration of azoxymethan and dextran sodium sulfate model |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 19 Feb 2019 14:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/663 |
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