Piffko, Andras and Yang, Kaiting and Panda, Arpit and Heide, Janna and Tesak, Krystyna and Wen, Chuangyu and Zawieracz, Katarzyna and Wang, Liangliang and Naccasha, Emile Z. and Bugno, Jason and Fu, Yanbin and Chen, Dapeng and Donle, Leonhard and Lengyel, Ernst and Tilley, Douglas G. and Mack, Matthias and Rock, Ronald S. and Chmura, Steven J. and Vokes, Everett E. and He, Chuan and Pitroda, Sean P. and Liang, Hua Laura and Weichselbaum, Ralph R. (2025) Radiation-induced amphiregulin drives tumour metastasis. NATURE, 643 (8072). ISSN 0028-0836, 1476-4687
Full text not available from this repository. (Request a copy)Abstract
The anti-tumour effect of radiotherapy beyond the treatment field-the abscopal effect-has garnered much interest1. However, the potentially deleterious effect of radiation in promoting metastasis is less well studied. Here we show that radiotherapy induces the expression of the EGFR ligand amphiregulin in tumour cells, which reprogrammes EGFR-expressing myeloid cells toward an immunosuppressive phenotype and reduces phagocytosis. This stimulates distant metastasis growth in human patients and in pre-clinical mouse tumour models. The inhibition of these tumour-promoting factors induced by radiotherapy may represent a novel therapeutic strategy to improve patient outcomes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR-RECEPTOR; CELL LUNG-CANCER; STEREOTACTIC BODY RADIOTHERAPY; SINGLE-CELL; T-CELLS; GENE-EXPRESSION; MACROPHAGES; GEFITINIB; EGFR; CHEMORADIOTHERAPY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Apr 2026 08:22 |
| Last Modified: | 01 Apr 2026 08:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67779 |
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