Manta, Ourania and Kikidis, Dimitris and Schlee, Winfried and Langguth, Berthold and Mazurek, Birgit and Lopez-Escamez, Jose A. and Martin-Lagos, Juan and Cima, Rilana and Bromis, Konstantinos and Vellidou, Eleftheria and Zachou, Zoi and Markatos, Nikos and Vassou, Evgenia and Kouris, Ioannis and Matsopoulos, George K. and Koutsouris, Dimitrios D. (2025) Electrophysiological Variations in Auditory Potentials in Chronic Tinnitus Individuals: Treatment Response and Tinnitus Laterality. JOURNAL OF CLINICAL MEDICINE, 14 (3): 760. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Background: This study investigates electrophysiological distinctions in auditory evoked potentials (AEPs) among individuals with chronic subjective tinnitus, with a specific focus on the impact of treatment response and tinnitus localisation. Methods: Early AEPs, known as Auditory Brainstem Responses (ABR), and middle AEPs, termed Auditory Middle Latency Responses (AMLR), were analysed in tinnitus patients across four clinical centers in an attempt to verify increased neuronal activity, in accordance with the current tinnitus models. Our statistical analyses primarily focused on discrepancies in time-domain core features of ABR and AMLR signals, including amplitudes and latencies, concerning both treatment response and tinnitus laterality. Results: Statistically significant differences were observed in ABR wave III and V latencies, ABR wave III peak amplitude, and AMLR wave Na and Nb amplitudes when comparing groups based on their response to treatment, accompanied by varying effect sizes. Conversely, when examining groups categorised by tinnitus laterality, no statistically significant differences emerged. Conclusions: These results provide valuable insights into the potential influence of treatment responses on AEPs. However, further research is imperative to attain a comprehensive understanding of the underlying mechanisms at play.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; tinnitus; chronic subjective tinnitus; auditory evoked potential; treatment response; tinnitus laterality; auditory brainstem response; auditory middle latency response; electrophysiological differences; statistical analysis; underlying mechanisms |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Psychosomatische Medizin Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Apr 2026 05:03 |
| Last Modified: | 01 Apr 2026 05:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67795 |
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